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Letter

FISH and immunohistochemical status of the hepatocyte growth factor receptor (c-Met) in 184 invasive breast tumors

Alma Carracedo123, Kristof Egervari4, Marta Salido13, Federico Rojo567, Josep M Corominas5, Montserrat Arumi568, Cristina Corzo9, Ignacio Tusquets10, Blanca Espinet13, Ana Rovira6, Joan Albanell106, Zoltan Szollosi4, Sergi Serrano5 and Francesc Solé13*

Author Affiliations

1 Servei de Patologia, Laboratori de Citogenètica Molecular, Hospital del Mar, IMAS, GRETNHE, IMIM, 08003 Barcelona, Spain

2 Departament de Biologia Cellular, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain

3 Escola de Citologia Hematològica S Woessner-IMAS, 08003 Barcelona, Spain

4 Department of Pathology, University of Debrecen MHSC, 4032 Debrecen, Hungary

5 Servei de Patologia, Unitat de Patologia Mamària, Hospital del Mar, UAB, 08003 Barcelona, Spain

6 Molecular Therapeutics and Biomarkers in Breast Cancer Program, IMIM-Hospital del Mar, 08003 Barcelona, Spain

7 Capio-Fundación Jiménez Díaz, 28040 Madrid, Spain

8 Department of Health and Experimental Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain

9 Escola Bonanova-IMAS, 08003 Barcelona, Spain

10 Oncology Department, Hospital del Mar, 08003 Barcelona, Spain

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Breast Cancer Research 2009, 11:402  doi:10.1186/bcr2239


See related research article by Götte et al., http://breast-cancer-research.com/content/9/1/R8

Published: 21 April 2009

First paragraph (this article has no abstract)

In their report, Götte and coworkers [1] analyzed the expression of c-Met in 200 patients with ductal carcinoma in situ. They concluded that c-Met could be related to angiogenic and lymphangiogenic factors in ductal carcinoma in situ. On the other hand, Greenberg and coworkers [2] studied 31 patients with ductal infiltrating carcinoma (DIC) to detect c-Met expression in their axillary fluids. They observed a correlation of c-Met expression with increasing tumor size and grade, capillary and lymphatic invasion and lymph node metastasis.