FISH and immunohistochemical status of the hepatocyte growth factor receptor (c-Met) in 184 invasive breast tumors

doi:10.1186/bcr2239

Breast Cancer Research

Volume 11
Issue 2

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Carracedo A
Egervari K
Salido M
Rojo F
Corominas JM
Arumi M
Corzo C
Tusquets I
Espinet B
Rovira A
Albanell J
Szollosi Z
Serrano S
Solé F

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Carracedo A
Egervari K
Salido M
Rojo F
Corominas JM
Arumi M
Corzo C
Tusquets I
Espinet B
Rovira A
Albanell J
Szollosi Z
Serrano S
Solé F
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FISH and immunohistochemical status of the hepatocyte growth factor receptor (c-Met) in 184 invasive breast tumors

Alma Carracedo¹^,2^,3 , Kristof Egervari⁴ , Marta Salido¹^,3 , Federico Rojo⁵^,6^,7 , Josep M Corominas⁵ , Montserrat Arumi⁵^,6^,8 , Cristina Corzo⁹ , Ignacio Tusquets¹⁰ , Blanca Espinet¹^,3 , Ana Rovira⁶ , Joan Albanell⁶^,10 , Zoltan Szollosi⁴ , Sergi Serrano⁵ and Francesc Solé¹^,3

¹Servei de Patologia, Laboratori de Citogenètica Molecular, Hospital del Mar, IMAS, GRETNHE, IMIM, 08003 Barcelona, Spain

²Departament de Biologia Cellular, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain

³Escola de Citologia Hematològica S Woessner-IMAS, 08003 Barcelona, Spain

⁴Department of Pathology, University of Debrecen MHSC, 4032 Debrecen, Hungary

⁵Servei de Patologia, Unitat de Patologia Mamària, Hospital del Mar, UAB, 08003 Barcelona, Spain

⁶Molecular Therapeutics and Biomarkers in Breast Cancer Program, IMIM-Hospital del Mar, 08003 Barcelona, Spain

⁷Capio-Fundación Jiménez Díaz, 28040 Madrid, Spain

⁸Department of Health and Experimental Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain

⁹Escola Bonanova-IMAS, 08003 Barcelona, Spain

¹⁰Oncology Department, Hospital del Mar, 08003 Barcelona, Spain

author email corresponding author email

Breast Cancer Research 2009, 11:402doi:10.1186/bcr2239


Published:	21 April 2009

See related research article by Götte et al., http://breast-cancer-research.com/content/9/1/R8

First paragraph (this article has no abstract)

In their report, Götte and coworkers [1] analyzed the expression of c-Met in 200 patients with ductal carcinoma in situ. They concluded that c-Met could be related to angiogenic and lymphangiogenic factors in ductal carcinoma in situ. On the other hand, Greenberg and coworkers [2] studied 31 patients with ductal infiltrating carcinoma (DIC) to detect c-Met expression in their axillary fluids. They observed a correlation of c-Met expression with increasing tumor size and grade, capillary and lymphatic invasion and lymph node metastasis.