Figure 5.

K6 and K14 expressing populations are increased in Wnt5a-/- and DNIIR tumours. Immunohistochemistry for K6 demonstrating the expansion of this progenitor population in (a) MMTV-PyVmT:Wnt5a-/- and (b) MMTV-PyVmT:DNIIR tumours compared with control groups (five per group). Immunohistochemistry for K14 in (c) MMTV-PyVmT:Wnt5a-/- and (d) MMTV-PyVmT:DNIIR tumours, along with representative controls (five per group). The K14 population in both Wnt5a-/- and DNIIR tumours displays a unique rounded morphology. DNIIR = dominant-negative transforming growth factor-β type II receptor; K = keratin; MMTV = mouse mammary tumour virus promoter/enhancer; PyVmT = polyoma virus middle T antigen; Wnt = Wingless-related protein family.