Figure 6.

Effects of celecoxib on iFGFR1-induced mammary tumourigenesis. (a to c) H&E-stained sections from non-transgenic control mice and mouse mammary tumour virus (MMTV) inducible fibroblast growth factor receptor 1 (iFGFR1) transgenic mice following treatment of mice with AP20187 in the presence or absence of celecoxib showing example of representative budding structures observed in each group of mice. Magnification bar = 50 μM. (d) Extent of epithelial budding was quantified in sections from the mice described in panel a. Structures were classified as either containing no discernible budding structures (none), one to three lateral buds (moderate), or four or more budding structures (extensive) Error bars represent standard error of the mean. ** P < 0.01, *** P < 0.001. NS = not significant.