Table 1 |
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Description of common abbreviations used in apoptosis and signal transduction |
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Abbreviation |
Meaning |
Synonyms |
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Bad |
Bcl-2/Bcl-XL-associated death domain protein |
BH3-only member of the Bcl-2 family |
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Bak |
Bcl-2 homologous antagonist-killer protein |
Multi-BH domain pro-apoptosis protein |
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Bax |
Bcl-2-associated X protein |
Multi-BH domain pro-apoptosis protein |
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Bcl-2 |
B-cell lymphoma-2 |
Defining member of the family; originally characterized as an oncogene |
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Bcl-XL |
Bcl-2-related gene, long form |
Bcl-XS is a shorter splice variant that is pro-apoptotic |
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Bim |
Bcl-2-interacting mediator of cell death |
BH3-only member of the Bcl-2 family |
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IκB |
Inhibitor of NF-κB |
Interacts with NF-κB |
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IKK |
IκB kinase |
Phosphorylates IκB to promote its degradation |
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MDM2 |
Murine double minute |
Negative regulator of the p53 tumor suppressor |
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NF-κB |
Nuclear factor-kappa type B |
Originally linked with enhancement of immunoglobulin kappa light-chain gene |
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p53 |
53 kDa protein |
Tumor-suppressor protein |
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PDK-1 |
3-phosphoinositide-dependent protein kinase 1 |
Master kinase that is crucial for the activation of Akt/PKB |
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PI3K |
Phosphoinositide 3-kinase |
Phosphatidylinositol 3-kinase; PI 3-kinase; PtdIns3K |
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PKB |
Protein kinase B |
Akt; RACK (related to A and C kinase); has PH domain |
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PMAIP-1/Noxa |
Phorbol-12-myristate-13-acetate-induced protein 1 |
BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis |
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PUMA |
p53-upregulated modulator of apoptosis |
BH3-only member of the Bcl-2 family |
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BH, Bcl-2 (B-cell lymphoma-2) homology. |
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Lewis-Wambi and Jordan Breast Cancer Research 2009 11:206 doi:10.1186/bcr2255 |
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