Table 6 |
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Correlation of mouse mammary stem-like gene expression and published breast tumor lung metastasis signatures |
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Lung metastasis signature: 14 genes, nine of which (64%) changed in stem-like stage |
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High at stem-like stage (9 genes) |
Low at stem-like stage (0 genes) |
Unchanged (5 genes) |
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Id1 – regulation of transcription |
Kynu – metabolic process |
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Tnc – cell adhesion |
Man1a1 – metabolic process |
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Ly6ea – cell surface receptor-linked signal transduction |
Vcam1 – membrane to membrane docking |
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Ltbp1 – growth factor binding |
Cxcr4 – apoptosis |
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Angptl4a – regulation of apoptosis |
Nedd9 – cell cycle/cell adhesion |
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Ptgs2 – regulation of cell proliferation |
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Cxcl1 – negative regulation of cell proliferation |
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Ereg – regulation of mitosis |
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Fscn1 – cell proliferation |
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From Minn et al. [38]. Names and biological process (as defined by gene ontology, selected and/or abbreviated to fit table) are provided. aHigh in pre-differentiated stage only. |
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Williams et al. Breast Cancer Research 2009 11:R26 doi:10.1186/bcr2256 |
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