Figure 1.

Time trends of age-adjusted breast cancer incidence and proportion of HER-2-positive breast cancer in the Pirkanmaan Hospital district from 1982 to 2005. Bullets = overall breast cancer incidence; rings = estimated incidence of human epidermal growth factor receptor 2 (HER-2)-negative breast cancer; closed squares = estimated incidence of HER-2-positive breast cancer; open squares = proportion of HER-2-positive breast cancer.