Research article
Dynamics of different-sized solid-state nanocrystals as tracers for a drug-delivery system in the interstitium of a human tumor xenograft
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* Corresponding author: Noriaki Ohuchi noriakio@mail.tains.tohoku.ac.jp
1 Division of Surgical Oncology, Tohoku University Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan
2 Department of Physics, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Japan
3 Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan
4 Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Naka-narusawa-cho, Hitachi, 316-8511, Japan
Breast Cancer Research 2009, 11:R43 doi:10.1186/bcr2330
Published: 3 July 2009Additional files
Additional file 1:
Picture of a dorsal skin-fold chamber. The skin between the chambers is sutured with 5-0 nylon around the window to locate the tumor in the center of the window. The tumor is exposed by incisions and then placed on a coverslip on the microscope.
Format: TIFF Size: 2.2MB Download file
Additional file 2:
Scheme of the optic system. It consists of an epifluorescence microscope, a Nipkow lens confocal unit, and an EMCCD camera.
Format: TIFF Size: 2.8MB Download file