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Dynamics of different-sized solid-state nanocrystals as tracers for a drug-delivery system in the interstitium of a human tumor xenograft

Masaaki Kawai1 email, Hideo Higuchi2 email, Motohiro Takeda3 email, Yoshio Kobayashi4 email and Noriaki Ohuchi1,3 email

Division of Surgical Oncology, Tohoku University Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan

Department of Physics, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Japan

Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan

Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Naka-narusawa-cho, Hitachi, 316-8511, Japan

author email corresponding author email

Breast Cancer Research 2009, 11:R43doi:10.1186/bcr2330

Published: 3 July 2009

Additional files

Additional file 1:

Picture of a dorsal skin-fold chamber. The skin between the chambers is sutured with 5-0 nylon around the window to locate the tumor in the center of the window. The tumor is exposed by incisions and then placed on a coverslip on the microscope.

Format: TIFF Size: 2.2MB Download file

Additional file 2:

Scheme of the optic system. It consists of an epifluorescence microscope, a Nipkow lens confocal unit, and an EMCCD camera.

Format: TIFF Size: 2.8MB Download file


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