Additional file 10.

A TIF file containing a figure that shows high expression of epidermal growth factor receptor (EGFR) gene products (only membrane staining was scored) in four of the nine non-luminal tumours displaying 'silent' genomes. High-level amplifications of the EGFR gene were found in two of these tumours and gain of the entire chromosome 7, where the EGFR gene resides, was found in one of them. High-level amplifications of the EGFR gene were not found anywhere else within the entire study group. (a) High expression of EGFR gene products (≥ 2+) in four example tumours, all of which displaying 'silent' genomes. The immunohistochemistry scores are indicated in each case. (b) High-level amplifications of the EGFR gene were found in two tumours displaying 'silent' genomes viewed here in 37.5 kb resolution (5×). (c) Chromosome 7 viewed in 7 kbp resolution (1×) of the same example genome with high-level amplification of the EGFR gene indicated.

Format: TIFF Size: 12.8MB Download file

Stefansson et al. Breast Cancer Research 2009 11:R47   doi:10.1186/bcr2334