BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

doi:10.1186/bcr2354

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BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Julian Puppe, Rinske Drost, Xiaoling Liu, Simon A Joosse, Bastiaan Evers, Paulien Cornelissen-Steijger, Petra Nederlof, Qiang Yu, Jos Jonkers^*^†, Maarten van Lohuizen^*^† and Alexandra M Pietersen^*^†

* Corresponding authors: Jos Jonkers j.jonkers@nki.nl - Maarten van Lohuizen m.v.lohuizen@nki.nl - Alexandra M Pietersen gmsamp@nus.edu.sg
† Equal contributors

Breast Cancer Research 2009, 11:R63 doi:10.1186/bcr2354

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BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

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BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A