Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer
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Correspondence: Max S Wicha mwicha@umich.edu
Breast Cancer Research 2009, 11:108 doi:10.1186/bcr2362
See related research by Puppe et al., http://breast-cancer-research.com/content/11/4/R63
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Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications Roberta Ciarapica, Lucio Miele, Antonio Giordano, Franco Locatelli, Rossella Rota BMC Medicine 2011, 9:63 (25 May 2011) Rota and colleagues review the role of the methyltransferase, EZH2, in the pathogenesis of pediatric soft tissue sarcomas, and discuss the therapeutic potential of epigenetic therapies in modulating EZH2 mediated gene repression.
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