Key signalling nodes in mammary gland development and cancer: Myc

doi:10.1186/bcr2406

Breast Cancer Research

Volume 11
Issue 5

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This article is part of a series on Key signalling nodes in mammary gland development and cancer, edited by Adrian Lee and Charles Streuli.

Review

Key signalling nodes in mammary gland development and cancer: Myc

Nancy E Hynes and Tina Stoelzle

Friedrich Miescher Institute for Biomedical Research, Maulbeerstraße 66, CH-4058 Basel, Switzerland

author email corresponding author email

Breast Cancer Research 2009, 11:210doi:10.1186/bcr2406


Published:	15 October 2009

Abstract

Myc has been intensely studied since its discovery more than 25 years ago. Insight has been gained into Myc's function in normal physiology, where its role appears to be organ specific, and in cancer where many mechanisms contribute to aberrant Myc expression. Numerous signals and pathways converge on Myc, which in turn acts on a continuously growing number of identified targets, via transcriptional and nontranscriptional mechanisms. This review will concentrate on Myc as a signaling mediator in the mammary gland, discussing its regulation and function during normal development, as well as its activation and roles in breast cancer.