Breast Cancer Research

official impact factor 5.79

Open Access Highly Access Research article

Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

Susan L Neuhausen1*, Sean Brummel2, Yuan C Ding1, Christian F Singer3, Georg Pfeiler3, Henry T Lynch4, Katherine L Nathanson5, Timothy R Rebbeck6, Judy E Garber7, Fergus Couch8, Jeffrey Weitzel9, Steven A Narod10, Patricia A Ganz11, Mary B Daly12, Andrew K Godwin13, Claudine Isaacs14, Olufunmilayo I Olopade15, Gail Tomlinson16, Wendy S Rubinstein17, Nadine Tung18, Joanne L Blum19 and Daniel L Gillen1,2

Author Affiliations

1 Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA

2 Department of Statistics, University of California Irvine, 2226 Bren Hall, Irvine, CA 92697 USA

3 Division of Special Gynecology, Department of Obstetrics and Gynaecology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria

4 Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68182, USA

5 Department of Medicine, Medical Genetics, University of Pennsylvania School of Medicine, 351 BRB 2/3, 421 Curie Blvd, Philadelphia, PA 19104, USA

6 Department of Biostatistics and Epidemiology Abramson Cancer Center University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA

7 Department of Adult Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA

8 Mayo Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA

9 Division of Clinical Cancer Genetics, Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA

10 Women's College Research Institute, Women's College Hospital, 790 Bay Street, 7th Floor, Toronto, ON M5G 1N8, Canada

11 UCLA Schools of Medicine and Public Health Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 CHS, Los Angeles, CA 90095-6900, USA

12 Department of Clinical Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA

13 Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA

14 Department of Medicine and Oncology, Georgetown University, 3800 Reservoir Road, NW, Washington, DC 20007, USA

15 Departments of Medicine and Human Genetics, University of Chicago, 5841 S. Maryland Avenue, MC2115, Chicago, IL 60637, USA

16 Division of Pediatric Hematology Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3901, USA

17 Department of Medicine, NorthShore University Health System, 1000 Central Street, Suite 620, Evanston, IL 60201, USA

18 Department of Medical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA

19 Department of Oncology, Baylor University Medical Center, 3535 Worth St. Suite 600, Dallas, TX 75246, USA

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Breast Cancer Research 2009, 11:R76 doi:10.1186/bcr2414

Published: 20 October 2009

Additional files

Additional file 1:

Word file containing a table that lists the LD blocks for the SNPs within each gene and the minor allele frequencies (MAF) for each SNP

Format: DOCX Size: 15KB Download file

Open Data