Table 2

Single SNP analysis results within significant linkage disequilibrium blocks for BRCA1 carriers

LD block^a

SNP

Genotype

n

Hazard ratio

95% confidence interval

P for trend

IRS1

1

rs1801278

GG

990

GA, AA

115

0.82

0.58, 1.17

1

rs13306465

GG

999

GA, AA

97

1.44

1.07, 1.94

1

rs1801123

AA

823

AG, GG

279

1.37

1.11, 1.69

IGF1R

11

rs8038415

CC

281

CT

536

1.11

0.88, 1.41

TT

270

1.40

1.07, 1.83

0.015

11

rs17847201

GG

350

GA

581

0.87

0.69, 1.10

AA

154

0.77

0.56, 1.05

0.091

IRS1, insulin-like growth factor receptor substrate 1; IGF1R, insulin-like growth factor-1 receptor. ^aLinkage disequilibrium (LD) block was defined by pairwise LD coefficient D' ≥ 0.90.

Neuhausen et al. Breast Cancer Research 2009 11:R76   doi:10.1186/bcr2414