Research article
PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro
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* Corresponding author: Richard S Finn rfinn@mednet.ucla.edu
1 Department of Medicine, Division of Hematology/Oncology, Geffen School of Medicine at UCLA, 10833 Le Conte Ave, 11-934 Factor Bldg, Los Angeles, CA 90095, USA
2 Pfizer Global Research and Development, Pfizer Inc., 10724 Science Center Drive, San Diego, CA 92121, USA
3 Pfizer Oncology BU, Clinical Development, Pfizer Inc., Via Lorenteggio 257, Milan 20152, Italy
Breast Cancer Research 2009, 11:R77 doi:10.1186/bcr2419
See related editorial by Sutherland and Musgrove, http://breast-cancer-research.com/content/11/6/112
Published: 29 October 2009Additional files
Additional file 1:
Excel file containing a table that lists the genes from the ANOVA of sensitive cell lines versus resistant cell lines.
Format: XLS Size: 342KB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 2:
PowerPoint file containing a figure that shows a Venn diagram demonstrating the overlap between resistant and nonluminal markers in breast cancer cell lines.
Format: PPT Size: 127KB Download file
This file can be viewed with: Microsoft PowerPoint Viewer
Additional file 3:
PowerPoint file containing a figure that shows a Venn diagram demonstrating the overlap between sensitive and luminal markers in breast cancer cell lines.
Format: PPT Size: 132KB Download file
This file can be viewed with: Microsoft PowerPoint Viewer
Additional file 4:
PowerPoint file containing a figure that shows a cluster of differentially expressed genes between the sensitive and resistant cell lines that excludes genes associated with cell subtype.
Format: PPT Size: 593KB Download file
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Additional file 5:
PowerPoint file containing a figure that shows a cycle analysis of PD 0332991 in combination with tamoxifen.
Format: PPT Size: 83KB Download file
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Additional file 6:
PowerPoint file containing a figure that shows a cycle analysis of PD 0332991 in combination with trastuzumab.
Format: PPT Size: 98KB Download file
This file can be viewed with: Microsoft PowerPoint Viewer