From normal cell types to malignant phenotypes
-
* Corresponding author: Cathrin Brisken cathrin.brisken@epfl.ch
Ecole polytechnique fédérale de Lausanne, ISREC - Swiss Institute for Experimental Cancer Research, CH-1015 Lausanne, Switzerland
Breast Cancer Research 2009, 11:306 doi:10.1186/bcr2418
Published: 9 November 2009Abstract
The phenotypic diversity of breast cancer has been proposed to result from different target cell types undergoing oncogenic transformation and giving rise to cancer stem cells. Global gene expression profiling revealed distinct molecular phenotypes and some of these signatures were held to reflect the cell of origin, with the basal carcinomas arising from basal/progenitor cells. Recent work challenges this view by providing evidence that luminal precursor cells are involved in the pathogenesis of basal breast cancers and has made new links between normal cell populations and molecular tumor phenotypes.