Research article
Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study
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* Corresponding author: Deborah J Thompson deborah.thompson@phpc.cam.ac.uk
1 Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
2 Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK
3 Gynaecological Cancer Research Centre, UCL EGA Institute for Women's Health, University College London, Gower Street, London, WC1E 6BT, UK
4 Department of Radiology, University of Cambridge, Addenbrookes Hospital NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK
5 Breast Screening Unit, Nightingale Centre & Genesis Prevention Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
6 Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Hathersage Road, Manchester, M13 0JH, UK
7 See Additional data file 1 for full authorship list
Breast Cancer Research 2009, 11:R80 doi:10.1186/bcr2447
Published: 11 November 2009Additional files
Additional file 2:
table S1 (genetic status of participants and probabilities of carrying BRCA1 or BRCA2 mutations for untested women and women with uninformative BRCA1/BRCA2 screening tests as predicted by the BOADICEA program), Table S2 (distributions of the MRI, Cumulus and Visual Assessment measures of breast dense volume and area) and Table S3 (breast cancer risk according to Cumulus and Visual Assessment percent dense area for the craniocaudal view and for the average density over the craniocaudal and medial-lateral oblique views).
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Additional file 3:
Figure S1 (scatter plots showing the relationships between measurements on the left and right breasts for MRI dense volume and percent dense volume, and for Cumulus dense area and percent dense area).
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Additional file 4:
Figure S2 (a scatter plot showing the relationship between MRI absolute dense volume and Cumulus absolute dense area).
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Additional file 1:
The full MARIBS authorship list.
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