Table 1 |
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|
Modification of 5-HT receptor expression with human breast cancer status - Oncomine study |
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|
Study Type |
Receptor Type |
Variable |
Direction of Change |
P-value (T-test) |
Oncomine data source |
|
|
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|
Tumor grade/stage |
HTR2B |
Normal vs Breast Carcinoma |
Higher in Cancer |
0.002 |
Richardson et. al. [77] |
|
Tumor stage N0-N3 |
Increase with stage |
0.006 |
Bittner et. al. [78] |
||
|
HTR2C |
Tumor stage N0-N3 |
Increase with stage |
0.009 |
Yu et. al. [79] |
|
|
HTR7 |
Grade I to III |
Increase with grade |
<0.0001 |
Ivshina et. al. [80] |
|
|
0.0001 |
Miller et. al. [81] |
||||
|
<0.01 |
Ginestier C et. al. [82] |
||||
|
More aggressive vs Less aggressive breast cancers |
HTR1F |
5 yrs recurrence- vs 5 yrs recurrence+ |
Higher in recurring tumors |
0.005 |
VantVeer et. al. [83] |
|
HTR2B |
Lymph node- vs Lymph node+ |
Higher in lymph node + |
0.006 |
Chin et. al. [84] |
|
|
HTR2C |
Primary vs Metastatic tumors |
Higher in metastatic |
0.001 |
Bittner et. al. [78] |
|
|
Her2/neu- vs Her2/neu+ |
Higher in Her2/neu+ |
0.00057 |
Minn et. al. [85] |
||
|
0.002 |
Hess KR et. al. [86] |
||||
|
HTR5A |
P53-mutant vs p53-WT |
Higher in p53-mutant |
<0.0001 |
Miller et. al. [81] |
|
|
HTR7 |
P53-mutant vs p53-WT |
Higher in p53-mutant |
0.008 |
Miller et. al. [81] |
|
|
Steroid receptor status |
HTR1F |
ER+ vs ER- |
Higher in ER+ |
0.0001 |
Sotiriou et. al. [87] |
|
HTR2B |
ER+ vs ER- |
Higher in ER+ |
0.00014 |
Wang et. al. [88] |
|
|
0.0004 |
Sotitiou et. al. [87] |
||||
|
0.00014 |
Desmedt et. al. [89] |
||||
|
Luminal vs Basal Tumors |
Lower in Basal (ER-) |
<0.0001 |
Farmer et. al. [90] |
||
|
HTR4 |
ER+ vs ER- |
Higher in ER+ |
0.001 |
Chi et. al. [84] |
|
|
HTR7 |
ER+ vs ER- |
Higher in ER+ |
<0.0001 |
VanderVijer et. al. [91] |
|
|
0.00087 |
Bittner et. al. [78] |
||||
|
Human Mammary Cell lines |
HTR2B |
HMEC-Normal (GFP) vs c-Myc transformation |
Higher in c-Myc transformed cells |
0.001 |
Bild AH et. al. [92] |
|
HTR7 |
HMEC-Normal (GFP) vs activated H-Ras |
Higher in H-Ras cells |
0.00028 |
Bild AH et. al. [92] |
|
|
|
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|
Receptor mRNAs encoding 5-HT1F (HTR1F), 5-HT2B (HTR2B), 5-HT2C (HTR2C), 5-HT4 (HTR4), 5-HT5A (HTR5A) and 5-HT7 (HTR7) sorted as per tumor stage/grade, ER status, tumor aggressiveness and human mammary cell line transformation. Abbreviations: (ER+) - Estrogen Receptor Positive, (ER-) - Estrogen Receptor Negative. (HMEC) - human mammary epithelial cells. |
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|
Pai et al. Breast Cancer Research 2009 11:R81 doi:10.1186/bcr2448 |
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