Research article
Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines
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* Corresponding author: Grégory Nolens gnolens@gmail.com
1 Laboratory of Molecular Oncology, GIGA Cancer, University of Liège, B34, avenue de l'hopital, Liege, 4000, Belgium
2 Department of Human Histology-CRPP, University of Liège, B36, avenue de l'hopital, Liege, 4000, Belgium
3 Laboratory of Mass Spectrometry; CART, GIGA, University of Liège, B6, avenue de la chimie, Liege, 4000, Belgium
Breast Cancer Research 2009, 11:R83 doi:10.1186/bcr2450
Published: 11 November 2009Additional files
Additional data file 1:
Mass Spectometry identification of the Ku proteins interacting with AP-2α.
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Additional file 2:
that Ku and AP-2 protein interaction is specific.
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Additional file 3:
effect of Ku70/Ku80 and AP-2 deregulation on ERBB2 mRNA and protein expression in SKBR3 cells.
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Additional file 4:
that Ku70/80 proteins control ERBB2 promoter activity in SKBR3 cell line.
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Additional file 5:
that Ku proteins are necessary for the recruitment of AP-2 on the proximal ERBB2 gene promoter in SKBR3 cell line.
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