Breast Cancer Research

official impact factor 5.79

Open Access Highly Access Research article

Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines

Grégory Nolens1*, Jean-Christophe Pignon1, Benjamin Koopmansch1, Benaïssa Elmoualij2, Willy Zorzi2, Edwin De Pauw3 and Rosita Winkler1

Author Affiliations

1 Laboratory of Molecular Oncology, GIGA Cancer, University of Liège, B34, avenue de l'hopital, Liege, 4000, Belgium

2 Department of Human Histology-CRPP, University of Liège, B36, avenue de l'hopital, Liege, 4000, Belgium

3 Laboratory of Mass Spectrometry; CART, GIGA, University of Liège, B6, avenue de la chimie, Liege, 4000, Belgium

For all author emails, please log on.

Breast Cancer Research 2009, 11:R83 doi:10.1186/bcr2450

Published: 11 November 2009

Additional files

Additional data file 1:

Mass Spectometry identification of the Ku proteins interacting with AP-2α.

Format: PDF Size: 54KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

that Ku and AP-2 protein interaction is specific.

Format: PDF Size: 931KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

effect of Ku70/Ku80 and AP-2 deregulation on ERBB2 mRNA and protein expression in SKBR3 cells.

Format: PDF Size: 1.6MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

that Ku70/80 proteins control ERBB2 promoter activity in SKBR3 cell line.

Format: PDF Size: 1.7MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

that Ku proteins are necessary for the recruitment of AP-2 on the proximal ERBB2 gene promoter in SKBR3 cell line.

Format: PDF Size: 1.8MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data