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Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines

Grégory Nolens1 email, Jean-Christophe Pignon1 email, Benjamin Koopmansch1 email, Benaïssa Elmoualij2 email, Willy Zorzi2 email, Edwin De Pauw3 email and Rosita Winkler1 email

Laboratory of Molecular Oncology, GIGA Cancer, University of Liège, B34, avenue de l'hopital, Liege, 4000, Belgium

Department of Human Histology-CRPP, University of Liège, B36, avenue de l'hopital, Liege, 4000, Belgium

Laboratory of Mass Spectrometry; CART, GIGA, University of Liège, B6, avenue de la chimie, Liege, 4000, Belgium

author email corresponding author email

Breast Cancer Research 2009, 11:R83doi:10.1186/bcr2450

Published: 11 November 2009

Additional files

Additional data file 1:

Mass Spectometry identification of the Ku proteins interacting with AP-2α.

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Additional file 2:

that Ku and AP-2 protein interaction is specific.

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Additional file 3:

effect of Ku70/Ku80 and AP-2 deregulation on ERBB2 mRNA and protein expression in SKBR3 cells.

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Additional file 4:

that Ku70/80 proteins control ERBB2 promoter activity in SKBR3 cell line.

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Additional file 5:

that Ku proteins are necessary for the recruitment of AP-2 on the proximal ERBB2 gene promoter in SKBR3 cell line.

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