Table 3 |
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|
Joint association of MTHFR C677T genotype and nutrient intakes on postmenopausal breast cancer risk, VITAL study *,† |
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|
MTHFR C677T genotype |
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|
CC |
CT |
TT |
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|
|
|
|
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|
Cases/controls |
Multivariate OR (95% CI) |
Cases/controls |
Multivariate OR (95% CI) |
Cases/controls |
Multivariate OR (95% CI) |
P for trend ‡ |
P for interaction § |
|
|
|
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|
Multivitamin use |
||||||||
|
Some |
92/218 |
1.00 |
108/213 |
1.20 (0.82-1.75) |
29/51 |
1.46 (0.83-2.56) |
0.24 |
|
|
None |
41/83 |
1.24 (0.75-2.03) |
31/71 |
0.90 (0.52-1.59) |
17/11 |
6.24 (2.37-16.4) |
0.02 |
0.27 |
|
Folate |
||||||||
|
Dietary folate (μg/day) |
||||||||
|
≥ 224 (median, high) |
79/128 |
1.00 |
68/135 |
0.85 (0.55-1.30) |
20/27 |
1.29 (0.66-2.52) |
0.86 |
|
|
<224 |
43/139 |
0.41 (0.25-0.67) |
55/126 |
0.60 (0.37-0.98) |
26/27 |
1.31 (0.66-2.63) |
<0.01 |
0.02 |
|
Supplemental folate (μg/day) # |
||||||||
|
≥ 400 |
48/129 |
1.00 |
58/119 |
1.28 (0.80-2.06) |
13/26 |
1.17 (0.54-2.54) |
0.53 |
|
|
<400 |
85/172 |
1.34(0.87-2.07) |
81/165 |
1.39 (0.89-2.15) |
33/36 |
2.69 (1.48-4.88) |
0.05 |
0.83 |
|
Total folate (DFE/day) |
||||||||
|
≥ 850 (median, high) |
54/132 |
1.00 |
65/127 |
1.26 (0.79-2.01) |
13/29 |
1.03 (0.48-2.22) |
0.74 |
|
|
<850 |
68/134 |
1.32 (0.83-2.09) |
57/130 |
1.19 (0.74-1.91) |
32/23 |
4.09 (2.08-8.04) |
0.01 |
0.19 |
|
Methionine |
||||||||
|
Dietary methionine (g/day) |
||||||||
|
≥ 1.38 (median, high) |
60/133 |
1.00 |
56/135 |
0.91 (0.58-1.44) |
19/23 |
1.89 (0.91-3.89) |
0.29 |
|
|
<1.38 |
62/134 |
1.07 (0.65-1.77) |
67/126 |
1.29 (0.78-2.13) |
27/31 |
2.10 (1.07-4.14) |
0.04 |
0.55 |
|
Vitamin B2 |
||||||||
|
Dietary vitamin B2 (mg/day) |
||||||||
|
≥ 1.81 (median, high) |
63/127 |
1.00 |
59/133 |
0.92 (0.58-1.44) |
18/29 |
1.23 (0.62-2.45) |
0.72 |
|
|
<1.81 |
59/140 |
0.85 (0.52-1.37) |
64/128 |
1.03 (0.63-1.68) |
28/25 |
2.53 (1.25-5.12) |
<0.01 |
0.06 |
|
Total vitamin B2 (mg/day) |
||||||||
|
≥ 2.70 (median, high) |
59/125 |
1.00 |
60/139 |
0.94 (0.59-1.48) |
16/26 |
1.27 (0.61-2.64) |
0.96 |
|
|
<2.70 |
63/142 |
1.02(0.64-1.63) |
63/122 |
1.23 (0.76-1.98) |
39/28 |
2.73 (1.40-5.33) |
0.02 |
0.10 |
|
Vitamin B6 |
||||||||
|
Dietary vitamin B6 (mg/day) |
||||||||
|
≥ 1.61 (median, high) |
59/129 |
1.00 |
54/132 |
0.93 (0.58-1.48) |
16/31 |
1.20 (0.59-2.45) |
0.97 |
|
|
<1.61 |
63/138 |
1.08 (0.66-1.77) |
69/129 |
1.26 (0.77-2.07) |
30/23 |
3.23 (1.58-6.61) |
<0.01 |
0.07 |
|
Supplemental vitamin B6 (mg/day) # |
||||||||
|
≥ 2.00 |
49/108 |
1.00 |
55/103 |
1.17 (0.72-1.90) |
10/25 |
0.69 (0.30-1.60) |
0.93 |
|
|
<2.00 |
84/192 |
0.87 (0.57-1.34) |
83/177 |
0.97 (0.62-1.50) |
36/35 |
2.31 (1.28-4.15) |
<0.01 |
0.11 |
|
Total vitamin B6 (mg/day) |
||||||||
|
≥ 3.32 (median, high) |
57/132 |
1.00 |
62/130 |
1.11 (0.70-1.76) |
12/32 |
0.72 (0.33-1.56) |
0.83 |
|
|
<3.32 |
65/135 |
1.11 (0.70-1.75) |
61/131 |
1.11 (0.70-1.76) |
34/22 |
4.47 (2.28-8.75) |
<0.01 |
0.01 |
|
Vitamin B12 |
||||||||
|
Dietary vitamin B12 (μg/day) |
||||||||
|
≥ 5.30 (median, high) |
52/131 |
1.00 |
57/133 |
1.13 (0.70-1.80) |
19/26 |
2.01 (0.99-4.11) |
0.15 |
|
|
<5.30 |
70/136 |
1.38 (0.85-2.22) |
66/128 |
1.38 (0.85-2.26) |
27/28 |
2.58 (1.31-5.08) |
0.10 |
0.85 |
|
Supplemental vitamin B12 (μg/day) # |
||||||||
|
≥ 6.00 |
56/120 |
1.00 |
69/109 |
1.30 (0.83-2.05) |
14/25 |
1.06 (0.50-2.25) |
0.44 |
|
|
<6.00 |
76/180 |
0.81 (0.53-1.24) |
70/171 |
0.83 (0.54-1.29) |
29/34 |
1.72 (0.94-3.15) |
0.04 |
0.65 |
|
Total vitamin B12 (μg/day) |
||||||||
|
≥ 11.4 (median, high) |
60/130 |
1.00 |
69/131 |
1.17 (0.75-1.83) |
17/33 |
1.15 (0.57-2.33) |
0.48 |
|
|
<11.4 |
62/137 |
0.98 (0.62-1.53) |
54/129 |
0.92 (0.58-1.47) |
29/21 |
3.06 (1.55-6.04) |
<0.01 |
0.17 |
|
Micronutrient score** |
||||||||
|
High (median) |
57/129 |
1.00 |
62/134 |
1.09 (0.69-1.73) |
13/27 |
1.05 (0.48-2.28) |
0.96 |
|
|
Low |
65/138 |
1.12 (0.70-1.80) |
61/127 |
1.15 (0.71-1.87) |
33/27 |
3.20 (1.66-6.19) |
<0.01 |
0.10 |
|
Total alcohol (g/d) |
||||||||
|
<10.0 (low) |
100/254 |
1.00 |
105/229 |
1.15 (0.81-1.65) |
38/53 |
2.12 (1.26-3.56) |
0.01 |
|
|
≥ 10.0 |
32/42 |
1.80 (1.02-3.15) |
30/48 |
1.34 (0.76-2.38) |
8/8 |
2.32 (0.79-6.85) |
0.84 |
0.22 |
|
|
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|
* All analyses adjusted for the following:age (50-54 years, 55-59, 60-64, 65-69, 70-76), race (white, other), family history of breast cancer (no, 1 affected mother or sister, ≥ 2 affected mother or sister(s)), mammography within two years preceding baseline(no, yes), history of breast biopsy (no, yes), age at menarche (≤ 11 years,12,13, ≥ 14), age at first birth (nulliparous, ≤ 19 years, 20-24, 25-34, ≥ 35), age at menopause (≤ 44 years,45-49, ≥ 50), years of combined estrogen and progestin postmenopausal hormones (PMH, never or <1 years,1-4,5-9, ≥ 10), height (<62 in, 62-<65, 65-<68, ≥ 68), body mass index (BMI) (<25 kg/m2,25-<30, ≥ 30), total physical activity (none, 1-3 tertiles of MET-hours/week), total energy intake (kcal/day), and for non-alcohol exposures, past-year alcohol intake (<1.5 g/day, 1.5-4.9, 5.0-9.9, ≥ 10). Energy was added to the models for all dietary and total nutrient exposures. † Case/control numbers do not add up to total due to missing data on nutrient intakes ‡ P for trend testing trend for MTHFR genotypes by strata of nutrient/alcohol intakes and calculated by modelling the MTHFR genotypes (CC, CT, and TT) as one term, ordinally §P for interaction testing whether the association between MTHFR and breast cancer varies by nutrient/alcohol intake Median intakes, based on distribution of nutrient intake from controls # Intakes of all supplements over 10 years; cutpoints represent amount in a 10 year daily use of standard multivitamin or greater ** Micronutrient score computed by summing the z-scores of folate, methionine, and vitamins B2, B6, B12 and then, dividing this sum into high (upper median) and low (lower median) groups. |
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|
Maruti et al. Breast Cancer Research 2009 11:R91 doi:10.1186/bcr2462 |
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