Table 4

Comparison of pathologic features of ER-positive BRCA1-associated breast cancers and ER-positive sporadic breast cancers

Covariates

BRCA1 +

Sporadic

n

%

N

%

Logistic likelihood ratio test P

All

47

100

138

100

Mean age in years (range)

46 (29-72)

46 (29-72)

Histologic type

Invasive ductal only

35

74

78

57

0.03

All others

12

26

60

43

Mixed ductal/lobular

10

21

25

18

Lobular

1

2

12

9

Mixed ductal + special type

0

0

8*

6

Special type

1⁺

2

15⁺⁺

11

Histologic grade

3

18

38

34

25

0.10

2

15

32

69

50

0.39

1

13

28

35

25

0.69

Unknown

1

2

0

0

Mitoses/10 HPF

>10

9

19

9

7

0.03

6-10

12

26

31

22

0.67

0-5

25

53

98

71

0.03

Unknown

1

2

0

0

Margins

Invasive

43

91

134

97

0.12

Pushing

3

6

2

1

0.09

Unknown

1

2

2

1

Lymphocytic infiltrate

Moderate/marked

2

4

17

12

0.08

None/mild

44

94

121

88

Unknown

1

2

0

0

Geographic necrosis/fibrotic focus

Yes

7

15

9

7

0.09

No

38

81

129

93

Unknown

2

4

0

0

ER, estrogen receptor; HPF, high powered field.

Percentages calculated by column

* Mixed ductal plus: mucinous (n = 4), invasive micropapillary (n = 2), invasive papillary (n = 1), tubular (n = 1)

+ tubular (n = 1)

++ tubular (n = 6), mucinous (n = 5), invasive micropapillary (n = 2), invasive cribriform (n = 1), mixed invasive

micropapillary/mucinous (n = 1)

Tung et al. Breast Cancer Research 2010 12:R12   doi:10.1186/bcr2478