Table 1

Comparison of fractionated irradiation effect on CIC population, CICs markers and corresponding sphere forming capacity.

MCF-7

CD24^Low/-/CD44^Hight

ZsGreen-cODC⁺

Dose

% of CICs (+/- SEM)

Sphere forming capacity

Sphere forming capacity

% of CICs (+/- SEM)

Dose

0

3.01 (+/- 0.61),

P value

9.4 (+/- 0.5),

P value

12.32 (+/- 2.01),

P value

2.17 (+/- 0.47),

P value

0

2

6.54 (+/- 1.95),

P = 0.095

13.49 (+/- 1.32),

P = 0.01

15.25 (+/- 3.2),

P = 0.661

3.70 (+/- 0.52),

P = 0.051

3

2 × 2

8.04 (+/- 1.47),

P = 0.036

10.76 (+/- 0.96),

P = 0.137

17.54 (+/- 4.15),

P = 0.096

3.13 (+/- 0.53),

P = 0.252

2 × 3

4 × 2

8.56 (+/- 1.21),

P = 0.020

11.85 (+/- 1.81),

P = 0.198

17.93 (+/- 2.33),

P = 0.051

6.73 (+/- 1.33),

P = 0.141

3 × 3

6 × 2

9.10 (+/- 1.04),

P = 0.029

11.85 (+/- 1.48),

P = 0.035

24.52 (+/- 4.50),

P = 0.048

11.26 (+/- 2.06),

P = 0.091

4 × 3

8 × 2

4.78 (+/- 0.34)

P = 0.229

11.85 (+/- 1.27),

P = 0.002

25.37 (+/- 5.2),

P = 0.039

12.64 (+/- 1.91),

P = 0.044

5 × 3

T47D

CD24^Low/-/CD44Hight

ZsGreen-cODC+

Dose

% of CICs (+/- SEM)

Sphere forming capacity

Sphere forming capcity

% of CICs (+/- SEM)

Dose

0

0.35 (+/- 0.06),

P value

9.46 (+/- 2.20),

P value

3.35 (+/- 2.01),

P value

2.47 (+/- 0.88),

P value

0

2

0.34 (+/- 0.03),

P = 0.868

6.74 (+/- 1.31),

P = 0.014

3.13 (+/- 2.69),

P = 0.231

4.31 (+/- 1.13),

P = 0.029

3

2 × 2

0.43 (+/- 0.08),

P = 0.471

13.76 (+/- 4.01),

P = 0.146

6.48 (+/- 3.14),

P = 0.091

9.72 (+/- 2.81),

P = 0.068

2 × 3

4 × 2

2.04 (+/- 0.12),

P = 0.001

12.74 (+/- 4.58),

P = 0.157

9.96 (+/- 2.33),

P = 0.049

16.09 (+/- 5.57),

P = 0.103

3 × 3

6 × 2

0.68 (+/- 0.04),

P = 0.007

17.99 (+/- 5.17),

P = 0.027

12 (+/- 2.66),

P = 0.033

24.06 (+/- 4.15),

P = 0.025

4 × 3

8 × 2

0.29 (+/- 0.01),

P = 0.449

18.92 (+/- 5.83),

P = 0.018

7.65 (+/- 2.55),

P = 0.055

21.133 (+/- 1.87),

P = 0.015

5 × 3

Lagadec et al. Breast Cancer Research 2010 12:R13   doi:10.1186/bcr2479