Editorial
Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?
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* Corresponding author: Sunil R Lakhani s.lakhani@uq.edu.au
1 Molecular & Cellular Pathology, University of Queensland Centre for Clinical Research, Level 6 Building 71/918, University of Queensland, The Royal Brisbane & Women's Hospital, Herston 4029, Brisbane, QLD, Australia
2 The Queensland Institute for Medical Research, 300 Herston Road, Herston, QLD 4006, Australia
Breast Cancer Research 2010, 12:104 doi:10.1186/bcr2483
Published: 19 March 2010Abstract
There is a strong association between BRCA1 mutation carrier status and estrogen receptor-negative breast cancer. This has led to the idea that estrogen receptor-positive breast cancers in BRCA1 mutation carriers may be incidental or sporadic in nature and not as a direct result of BRCA1 dysfunction. A recent paper in Breast Cancer Research challenges this view.