Table 3

Duration and intensity of NSAID¤ use among women with ≥ 10 years of prescription history

Characteristics

Cases*

Controls*

Odds Ratio

95% Confidence Interval

N

%

N

%

Never/rare

1,188

50

12,714

53

1.00

Shorter-term <10 years:

Low Intensity†

317

13

2,997

13

1.09

0.96 to 1.25

Medium Intensity‡

210

9

2,078

9

1.03

0.88 to 1.20

High Intensity⁺

332

14

2,961

12

1.16

1.01 to 1.33

Long-term 10 to </= 15 years:

Low Intensity†

151

6

1,301

5

1.18

0.98 to 1.42

Medium Intensity‡

81

3

773

3

1.06

0.83 to 1.35

High Intensity⁺

88

4

971

4

0.90

0.71 to 1.13

Long-term >15 years:

Low Intensity†

6

0.3

76

0.3

0.80

0.35 to 1.85

Medium Intensity‡

16

0.7

74

0.3

2.30

1.30 to 4.06

High Intensity⁺

10

0.4

96

0.4

1.01

0.52 to 1.97

¤(sCox-2 inhibitors, aspirin, and non-aspirin non-selective NSAID). * Matched on county of residence and birth year. ^Analyses adjusted for use of hormone replacement therapy, history of rheumatoid arthritis and migraine. † Low intensity was prescription use <25% of duration. ‡ Medium intensity was prescription use >25% but <50% of duration. ⁺ High intensity was prescription use >50% of duration.

Cronin-Fenton et al. Breast Cancer Research 2010 12:R15   doi:10.1186/bcr2482