Research article
Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer
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* Corresponding author: Jingmei Li Jingmei.Li@ki.se
1 Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Box 281, 171 77 Stockholm, Sweden
2 Human Genetics, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore
3 Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
4 Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
5 Program in Genetic and Molecular Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
6 Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
7 Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
8 Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 Mikras Asias Str, Goudi, Athens 115 27, Greece
Breast Cancer Research 2010, 12:R19 doi:10.1186/bcr2488
Published: 9 March 2010Additional files
Additional file 1:
Tables S1 to S3. Table S1 presents a list of SNPs in the androgen synthesis subpathway and their corresponding regression coefficients and likelihood ratio test P values. Table S2 presents a list of SNPs in the androgen to estrogen conversion subpathway and their corresponding regression coefficients and likelihood ratio test P values. Table S3 presents a list of SNPs in the estrogen removal subpathway and their corresponding regression coefficients and likelihood ratio test P values.
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Additional file 2:
Table S4. Table S4 presents genes containing polymorphisms within the estrogen metabolic pathway evaluated in relation to mammographic density.
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Additional file 3:
Table S5. Table S5 presents validation results of significantly associated SNPs in the Nurses' Health Study (NHS) and the Mayo Clinic Breast Cancer Study (MBCS).
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