Research article
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
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* Corresponding author: Jane E Visvader visvader@wehi.edu.au
- † Equal contributors
1 The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
2 Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia
3 Department of Immunology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
4 Department of Medical Oncology, The Royal Melbourne Hospital, Grattan St, Parkville, VIC 3050, Australia
5 Department of Medicine, The University of Melbourne, The Royal Melbourne Hospital, Clinical Sciences Building, Parkville, VIC 3050, Australia
Breast Cancer Research 2010, 12:R21 doi:10.1186/bcr2560
See related editorial by McDermott and Wicha, http://breast-cancer-research.com/content/12/3/108
Published: 26 March 2010Additional files
Additional file 1:
Supplementary methods. This file contains primer sequences.
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Additional file 2:
Expression of CD24. A figure demonstrating that CD24 is expressed in the luminal progenitor and mature luminal populations from human breast tissue.
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Additional file 3:
A heat map and multidimension scaling plot of mouse mammary populations. Includes the MaSC-enriched (CD29hiCD24+), luminal progenitor (CD29loCD24+CD61+), mature luminal (CD29loCD24+CD61-), and stromal (CD29loCD24-) subpopulations.
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Additional file 4:
Supplementary Table 1 containing conserved genes in the MaSC-enriched subset. The table gives the 489 genes which are up-regulated and the 428 genes which are down-regulated in the MaSC-enriched subset in both species.
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Additional file 5:
Supplementary Table 2 containing conserved genes in the luminal progenitor subset. The table gives the 58 genes which are up-regulated and the 14 genes which are down-regulated in the luminal progenitor subset in both species.
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Additional file 6:
Supplementary Table 3 containing conserved genes in the mature luminal subset. The table gives the 116 genes which are up-regulated and the 99 genes which are down-regulated in the mature luminal subset in both species.
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