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Volume 12 Issue 4
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Comment |
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Tumor senescence and radioresistant tumor-initiating cells (TICs): let sleeping dogs lie!
Gaetano Zafarana, Robert G Bristow Breast Cancer Research 2010, 12:111 (5 July 2010)
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Microarray data analysis in neoadjuvant biomarker studies in estrogen receptor-positive breast cancer
Jingqin Luo, Matthew J Ellis Breast Cancer Research 2010, 12:112 (20 August 2010)
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BRCA1: linking HOX to breast cancer suppression
Kideok Jin, Saraswati Sukumar Breast Cancer Research 2010, 12:306 (23 July 2010)
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Spatial organization acts on cell signaling: how physical force contributes to the development of cancer
Marija Plodinec, Cora-Ann Schoenenberger Breast Cancer Research 2010, 12:308 (23 August 2010)
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A prophylactic vaccine for breast cancer?
Christine J Watson, Barry A Gusterson Breast Cancer Research 2010, 12:310 (31 August 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Ovarian steroid hormones: what's hot in the stem cell pool?
Diana M Cittelly, Jennifer K Richer, Carol A Sartorius Breast Cancer Research 2010, 12:309 (31 August 2010)
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Review |
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Breast cancer prognostic classification in the molecular era: the role of histological grade
Emad A Rakha, Jorge S Reis-Filho, Frederick Baehner, David J Dabbs, Thomas Decker, Vincenzo Eusebi, Stephen B Fox, Shu Ichihara, Jocelyne Jacquemier, Sunil R Lakhani, José Palacios, Andrea L Richardson, Stuart J Schnitt, Fernando C Schmitt, Puay-Hoon Tan, Gary M Tse, Sunil Badve, Ian O Ellis Breast Cancer Research 2010, 12:207 (30 July 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The Met oncogene and basal-like breast cancer: another culprit to watch out for?
Stefania Gastaldi, Paolo M Comoglio, Livio Trusolino Breast Cancer Research 2010, 12:208 (23 August 2010)
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Report |
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What's new on circulating tumor cells? A meeting report
Evi S Lianidou, Dimitris Mavroudis, Georgia Sotiropoulou, Sophia Agelaki, Klaus Pantel Breast Cancer Research 2010, 12:307 (23 July 2010)
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Research |
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Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells
Ansgar Brüning, Klaus Friese, Alexander Burges, Ioannis Mylonas Breast Cancer Research 2010, 12:R45 (1 July 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
Leonard Da Silva, Peter T Simpson, Chanel E Smart, Sibylle Cocciardi, Nic Waddell, Annette Lane, Brian J Morrison, Ana Vargas, Sue Healey, Jonathan Beesley, Pria Pakkiri, Suzanne Parry, Nyoman Kurniawan, Lynne Reid, Patricia Keith, Paulo Faria, Emilio Pereira, Alena Skalova, Michael Bilous, Rosemary L Balleine, Hongdo Do, Alexander Dobrovic, Stephen Fox, Marcello Franco, Brent Reynolds, Kum Khanna, Margaret Cummings, Georgia Chenevix-Trench, Sunil R Lakhani Breast Cancer Research 2010, 12:R46 (6 July 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Deregulated epidermal growth factor receptors are involved in the colonisation of brain metastases from breast cancer, but downstream oncogenic mutations, which may drive treatment resistance, also warrant further investigation.
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Mammostrat® as a tool to stratify breast cancer patients at risk of recurrence during endocrine therapy
John MS Bartlett, Jeremy Thomas, Douglas T Ross, Robert S Seitz, Brian Z Ring, Rodney A Beck, Hans Christian Pedersen, Alison Munro, Ian H Kunkler, Fiona M Campbell, Wilma Jack, Gillian R Kerr, Laura Johnstone, David A Cameron, Udi Chetty Breast Cancer Research 2010, 12:R47 (8 July 2010)
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Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule
Hazem Ghebeh, Cynthia Lehe, Eman Barhoush, Khaldoon Al-Romaih, Asma Tulbah, Monther Al-Alwan, Siti-Faujiah Hendrayani, Pulicat Manogaran, Ayodele Alaiya, Taher Al-Tweigeri, Abdelilah Aboussekhra, Said Dermime Breast Cancer Research 2010, 12:R48 (13 July 2010)
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Gonadotropin-releasing hormone type II antagonist induces apoptosis in MCF-7 and triple-negative MDA-MB-231 human breast cancer cells in vitro and in vivo
Carsten Gründker, Crispin Föst, Stefanie Fister, Nadine Nolte, Andreas R Günthert, Günter Emons Breast Cancer Research 2010, 12:R49 (14 July 2010)
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Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
Adalgeir Arason, Haukur Gunnarsson, Gudrun Johannesdottir, Kristjan Jonasson, Pär-Ola Bendahl, Elizabeth M Gillanders, Bjarni A Agnarsson, Göran Jönsson, Katri Pylkäs, Aki Mustonen, Tuomas Heikkinen, Kristiina Aittomäki, Carl Blomqvist, Beatrice Melin, Oskar TH Johannsson, Pål Møller, Robert Winqvist, Heli Nevanlinna, Åke Borg, Rosa B Barkardottir Breast Cancer Research 2010, 12:R50 (16 July 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines
Annika N Alexopoulou, Maria Leao, Otavia L Caballero, Leonard Da Silva, Lynne Reid, Sunil R Lakhani, Andrew J Simpson, John F Marshall, A Munro Neville, Parmjit S Jat Breast Cancer Research 2010, 12:R51 (19 July 2010)
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Changes in expression of oestrogen regulated and proliferation genes with neoadjuvant treatment highlight heterogeneity of clinical resistance to the aromatase inhibitor, letrozole
William R Miller, Alexey Larionov Breast Cancer Research 2010, 12:R52 (20 July 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Predictive relevance of HOXB13 protein expression for tamoxifen benefit in breast cancer
Piiha-Lotta Jerevall, Agneta Jansson, Tommy Fornander, Lambert Skoog, Bo Nordenskjöld, Olle Stål Breast Cancer Research 2010, 12:R53 (22 July 2010)
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Editor’s summary
Low or absent protein expression of HOXB13, a member of the homeobox gene family, is predictive of adjuvant tamoxifen therapy response in terms of longer breast cancer survival for tamoxifen treated patients.
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Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study
Bassam Ghabach, William F Anderson, Rochelle E Curtis, Mark M Huycke, Jackie A Lavigne, Graça M Dores Breast Cancer Research 2010, 12:R54 (23 July 2010)
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Editor’s summary
Adenoid cystic carcinoma of the breast is characterized by estrogen receptor-negative/progesterone receptor-negative expression, rare regional lymph node involvement, a favourable prognosis with excellent survival, and absence of associated cancers.
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MYB suppresses differentiation and apoptosis of human breast cancer cells
Yvette Drabsch, Robert G Ramsay, Thomas J Gonda Breast Cancer Research 2010, 12:R55 (26 July 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67
Vilppu J Tuominen, Sanna Ruotoistenmäki, Arttu Viitanen, Mervi Jumppanen, Jorma Isola Breast Cancer Research 2010, 12:R56 (27 July 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Association of invasion-promoting tenascin-C additional domains with breast cancers in young women
David S Guttery, Rachael A Hancox, Kellie T Mulligan, Simon Hughes, Sinead M Lambe, J Howard Pringle, Rosemary A Walker, J Louise Jones, Jacqueline A Shaw Breast Cancer Research 2010, 12:R57 (2 August 2010)
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Editor’s summary
A significant association was found between additional domain containing tenascin-C isoforms and breast cancers in young women, which may have important functional significance in vivo.
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Breast cancer incidence and overdiagnosis in Catalonia (Spain)
Montserrat Martinez-Alonso, Ester Vilaprinyo, Rafael Marcos-Gragera, Montserrat Rue Breast Cancer Research 2010, 12:R58 (3 August 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Mammography screening contributed to overdiagnosis of breast cancer in Catalonia by detecting cases of tumours with limited malignant potential which would otherwise have gone undetected during a lifetime.
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Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro
Fiona Lanigan, Gabriela Gremel, Rowena Hughes, Donal J Brennan, Finian Martin, Karin Jirström, William M Gallagher Breast Cancer Research 2010, 12:R59 (3 August 2010)
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Editor’s summary
Increased expression of the transcription factor Msx2 resulted in improved outcome for breast cancer patients, possibly by increasing the likelihood of tumour cell death by apoptosis.
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Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells
Nancy E Castro, Carol A Lange Breast Cancer Research 2010, 12:R60 (5 August 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Columnar cell lesions and subsequent breast cancer risk: a nested case-control study
Sarah A Aroner, Laura C Collins, Stuart J Schnitt, James L Connolly, Graham A Colditz, Rulla M Tamimi Breast Cancer Research 2010, 12:R61 (6 August 2010)
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Anti-tumor effects of retinoids combined with trastuzumab or tamoxifen in breast cancer cells: induction of apoptosis by retinoid/trastuzumab combinations
Debbie C Koay, Cynthia Zerillo, Murli Narayan, Lyndsay N Harris, Michael P DiGiovanna Breast Cancer Research 2010, 12:R62 (9 August 2010)
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Editor’s summary
Combining retinoids with tamoxifen, trastuzumab or both synergistically inhibits cell growth, and retinoid/trastuzumab-containing combinations induce apoptosis in trastuzumab-sensitive cells, potentially benefiting breast cancer patients as a new therapy.
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Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations
Guillaume Banneau, Mickaël Guedj, Gaëtan MacGrogan, Isabelle de Mascarel, Valerie Velasco, Renaud Schiappa, Valerie Bonadona, Albert David, Catherine Dugast, Brigitte Gilbert-Dussardier, Olivier Ingster, Pierre Vabres, Frederic Caux, Aurelien de Reynies, Richard Iggo, Nicolas Sevenet, Françoise Bonnet, Michel Longy Breast Cancer Research 2010, 12:R63 (16 August 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen
Jean E Abraham, Mel J Maranian, Kristy E Driver, Radka Platte, Bolot Kalmyrzaev, Caroline Baynes, Craig Luccarini, Mitul Shah, Susan Ingle, David Greenberg, Helena M Earl, Alison M Dunning, Paul DP Pharoah, Carlos Caldas Breast Cancer Research 2010, 12:R64 (23 August 2010)
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Editor’s summary
The link between the CYP2D6 gene and breast cancer specific survival was found to be weak, shedding new light on whether it should be used to test predicted tamoxifen efficacy.
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Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density
Vilde D Haakensen, Margarethe Biong, Ole Lingjærde, Marit Holmen, Jan Frantzen, Ying Chen, Dina Navjord, Linda Romundstad, Torben Lüders, Ida K Bukholm, Hiroko K Solvang, Vessela N Kristensen, Giske Ursin, Anne-Lise Børresen-Dale, Åslaug Helland Breast Cancer Research 2010, 12:R65 (27 August 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Down-regulation of uridine 5'-diphosphoglucuronosyltransferase genes in women exposed to female sex hormones is associated with high mammographic density and might increase the risk of breast cancer.
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Correspondence |
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Managing bone health in women with breast cancer under adjuvant treatment with aromatase inhibitors: pretreatment bone mineral density is important
Christos Markopoulos Breast Cancer Research 2010, 12:403 (3 August 2010)
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RAD51C germline mutations in breast and ovarian cancer patients
Mohammad R Akbari, Patricia Tonin, William D Foulkes, Parviz Ghadirian, Marc Tischkowitz, Steven A Narod Breast Cancer Research 2010, 12:404 (19 August 2010)
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