Research article
HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
-
* Corresponding author: Sunil R Lakhani s.lakhani@uq.edu.au
1 Molecular & Cellular Pathology, The University of Queensland Centre for Clinical Research, & School of Medicine, Building 918/B71, RBWH complex, Brisbane, 4029, Australia
2 Cancer Genetics and Molecular Pathology, The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, 4006, Australia
3 Departamento de Anatomia Patológica, Universidade Federal de São Paulo, EPM, 754 Rua Napoleão de Barros, São Paulo, 04024-000, Brazil
4 Biomolecular and Biomedical Science, Griffith University, 170 Kessels Road, Brisbane, 4011, Australia
5 Centre for Magnetic Resonance, The University of Queensland, St Lucia, Brisbane, 4072, Australia
6 Lembaga Eijkman, Eijkman Institute, Diponegoro 69, Jakarta, 10430, Indonesia
7 Departamento de Patologia, Instituto Nacional de Câncer, 23 Praça Cruz Vermelha, Rio de Janeiro, 20230-130, Brazil
8 Departamento de Patologia, Laboratório Salomão & Zoppi, 48 Rua Correia Dias, São Paulo, 04104-000, Brazil
9 Department of Pathology, Medical Faculty of Charles University in Plzen, Husova 3, 306 05, Czech Republic
10 Sydney West Area Health Service, Institute of Clinical Pathology and Medical Research, University of Sydney, Darcy Road, Sydney, 2145, Australia
11 Translational Oncology, Sydney West Area Health Service, Westmead Millennium Institute, University of Sydney, Darcy Road, Sydney, 2145, Australia
12 Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Pl, East Melbourne, 3002, Australia
13 Queensland Brain Institute, The University of Queensland, St Lucia, Brisbane, 4072, Australia
14 Signal Transduction, The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, 4006, Australia
15 Pathology Queensland: The Royal Brisbane & Women's Hospital, Herston Road, Brisbane, 4029, Australia
16 Current address - University of Florida, McKnight Brain Institute,100 S. Newell Drive, Gainesville, 32611, USA
Breast Cancer Research 2010, 12:R46 doi:10.1186/bcr2603
Published: 6 July 2010Additional files
Additional file 1:
Supplementary methodologies. This file contains information of how the morphological review and TMA creation were performed. It also contains information on protocols for immunohistochemistry and chromogenic in situ hybridization, RNA extraction and Real-Time RT-PCR, DASL gene expression profiling, cell line analysis and culture, oncoCarta somatic mutation analysis protocols, high resolution melt analysis and iPLEX genotyping protocols.
Format: DOC Size: 121KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 2:
Supplementary results. This file contains tables and figures regarding all immunohistochemistry data, extra gene expression and mutation results, and HER family gene expression by RT-PCR.
Format: DOC Size: 557KB Download file
This file can be viewed with: Microsoft Word Viewer