Research article
CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen
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* Corresponding author: Jean E Abraham ja344@medschl.cam.ac.uk
1 Department of Oncology, Strangeways Research Laboratory, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
2 Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Hills Road, Cambridge, CB2 0QQ, UK
3 Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
4 Eastern Cancer Registration and Information Centre, Unit C-Magog Court, Shelford Bottom, Hinton Way, Cambridge, CB22 3AD, UK
Breast Cancer Research 2010, 12:R64 doi:10.1186/bcr2629
Published: 23 August 2010Additional files
Additional file 1:
Supplementary tables S1 to S6 and S8. Supplementary table S1: CYP2D6 inhibitors. A table containing the generic and trade names of CYP2D6 inhibitor drugs used by patients in the study. Supplementary table S2: All Functional and TagSNPs attempted. A table containing all the functional and tagSNPs attempted including those which failed. Supplementary table S3: Power calculations. Tabulated summary of power available in this study for each variant. Supplementary table S4: Genotype and allele frequencies. Tabulated summary of genotype and allele frequencies for each variant. Also the number of deaths (all-cause) in tamoxifen-treated patients. Supplementary table S5: Genotype frequencies and results of unadjusted and adjusted Cox regression analysis of common (tagSNPs) and functional polymorphisms and overall survival. Supplementary table S6: Full unadjusted CYP2D6 survival analysis independent of tamoxifen status. Tabulated summary of the full unadjusted CYP2D6 survival analysis independent of tamoxifen status. Supplementary table S8: Summary of previous studies. Tabulated summary of previous studies relating to CYP2D6 variants, clinical response and tamoxifen.
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Additional file 2:
Supplementary figure S1: Sequence alignment. The figure and supporting legends showing the primers and sequences for CYP2D6 and its known pseudogenes.
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Additional file 3:
Supplementary table S7: Adherence to REMARK criteria. Details of the REMARK criteria and how we have adhered to it.
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