Breast Cancer Research

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Open Access Highly Access Research article

Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density

Vilde D Haakensen1,2, Margarethe Biong1, Ole C Lingjærde3,4, Marit M Holmen5, Jan O Frantzen6, Ying Chen7, Dina Navjord8, Linda Romundstad9, Torben Lüders10, Ida K Bukholm11,2, Hiroko K Solvang1, Vessela N Kristensen1,10,2, Giske Ursin12,13, Anne-Lise Børresen-Dale1,2 and Åslaug Helland1,14,2*

Author Affiliations

1 Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Montebello, NO-0310, Norway

2 Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NO-0315, Norway

3 Biomedical Research Group, Department of Informatics, University of Oslo, Oslo, NO-0315, Norway

4 Centre for Cancer Biomedicine, University of Oslo, Oslo, NO-0315, Norway

5 Department of Radiology, Oslo University Hospital Radiumhospitalet, Oslo, NO-0310, Norway

6 Department of Radiology, University Hospital of North Norway, Tromsø, NO- 9038, Norway

7 Department. of Pathology, Vestfold Hospital, Halfdan Wilhelmsens Alle' 17, Tønsberg, NO-3103, Norway

8 Department of Radiology, Innlandet Hospital, Brummundal, NO-2381, Norway

9 Department of Radiology, Buskerud Hospital, Drammen, NO-3004, Norway

10 Department for Clinical Molecular Biology (EpiGen), Institute for Clinical Medicine, Akershus University Hospital, University of Oslo, Oslo, NO-0315, Norway

11 Department of Surgery, Akerhus University Hospital, Lørenskog, 1478, Norway

12 Department of Nutrition, School of Medicine, University of Oslo, Oslo, NO-0315, Norway

13 Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA

14 Department of Oncology, Oslo University Hospital Radiumhospitalet, Oslo, NO-0310, Norway

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Breast Cancer Research 2010, 12:R65 doi:10.1186/bcr2632

Published: 27 August 2010

Additional files

Additional file 1:

Healthy SAM MD. Significance analysis of microarrays (SAM) for genes differentially expressed according to mammographic density (MD).

Format: XLSX Size: 10.5MB Download file

Open Data

Additional file 2:

Figures and tables. A collection of figures and tables describing the data set and the uridine 5'-diphospho-glucuronosyltransferase (UGT) genes. The main text refers to individual figures and tables in this file.

Format: PDF Size: 300KB Download file

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Additional file 3:

Healthy SAM MD stratified. Significance analysis of microarrays (SAM) for genes differentially expressed according to mammographic density (MD) stratified on age and use of hormone therapy.

Format: XLSX Size: 15KB Download file

Open Data

Additional file 4:

eQTL. Expression quantitative trait loci (eQTL) analysis of single nucleotide polymorphism (SNPs) affecting the expression of uridine 5'-diphospho-glucuronosyltransferase (UGT) genes in cis.

Format: XLSX Size: 31KB Download file

Open Data