Research article
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
-
* Corresponding author: Charles M Perou cperou@med.unc.edu
- † Equal contributors
1 Lineberger Comprehensive Cancer Center, University of North Carolina, 450 West Drive, Chapel Hill, 27599, USA
2 Department of Genetics, University of North Carolina, 450 West Drive, Chapel Hill, 27599, USA
3 Department of Pathology & Laboratory Medicine, University of North Carolina, 450 West Drive, Chapel Hill, 27599, USA
4 Department of Molecular & Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, USA
Breast Cancer Research 2010, 12:R68 doi:10.1186/bcr2635
Published: 2 September 2010Additional files
Additional file 1:
Supplementary Tables S1-S5 and Supplementary Figures S1-S10. Table S1. Biological processes and signaling pathways enriched in claudin-low vs. basal-like tumors. Table S2. Biological processes and signaling pathways enriched in claudin-low tumors vs. rest. Table S3. Identification of the claudin-low subtype in a panel of breast cancer cell lines. Table S4. Histological examination of claudin-low tumors. Table S5. Evaluation of the intrinsic breast cancer molecular subtypes in histologically diverse types. Figure S1. Intrinsic unsupervised hierarchical clustering of the UNC337 database. Figure S2. Average expression of additional selected genes and gene signatures across the breast cancer subtypes. Figure S3. E-cadherin and claudin 3 immunohistochemical staining of breast tumors. Figure S4. Intrinsic gene set analysis of 52 breast cancer cell lines. Figure S5. Claudin-low tumor and normal breast predictions in 52 breast cancer cell lines. Figure S6. Average expression of genes and gene signatures across the various mouse classes. Figure S7. Differentiation predictions in Raouf et al. [23] database. Figure S8. Expression of the nine-cell line claudin-low predictor across different subpopulations of the normal breast. Figure S9. Mean expression of the top highly expressed (n = 833) and low expressed (n = 642) genes in claudin-low cell lines across 337 human breast tumor samples classified according to intrinsic subtype, including the normal breast-like group. Figure S10. Localization of five claudin-low samples (BC00054, 020018B, BC00075, 010384B, and BC00083) in the UNC337 intrinsic clustering.
Format: PDF Size: 6.8MB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 2:
Supplemental Data. Clinical data and gene lists reported throughout the manuscript.
Format: XLS Size: 2.3MB Download file
This file can be viewed with: Microsoft Excel Viewer