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Volume 13 Issue 3
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Comment |
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Endocrine resistance in breast cancer: new roles for ErbB3 and ErbB4
Robert L Sutherland Breast Cancer Research 2011, 13:106 (20 May 2011)
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From bone to breast and back - the bone cytokine RANKL and breast cancer
Lorenz C Hofbauer, Tilman D Rachner, Christine Hamann Breast Cancer Research 2011, 13:107 (25 May 2011)
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Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?
François Vaillant, Geoffrey J Lindeman, Jane E Visvader Breast Cancer Research 2011, 13:108 (25 May 2011)
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Spotlight on Geminin
Melvin L DePamphilis Breast Cancer Research 2011, 13:109 (1 June 2011)
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miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
Derek C Radisky Breast Cancer Research 2011, 13:110 (10 June 2011)
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Heating cancer stem cells to reduce tumor relapse
Pier Pelicci, Paola Dalton, Roberto Orecchia Breast Cancer Research 2011, 13:305 (6 May 2011)
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Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors
Alexey V Bazarov, Paul Yaswen Breast Cancer Research 2011, 13:308 (25 May 2011)
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EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells
Olafur Stefansson, Manel Esteller Breast Cancer Research 2011, 13:309 (25 May 2011)
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Waking up dormant tumors
Joyce C Tse, Raghu Kalluri Breast Cancer Research 2011, 13:310 (10 June 2011)
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Editor’s summary
Tse and Kalluri discuss a recent study identifying the relationship between cancer and distant bone marrow cells to support the growth of indolent tumour cells at a secondary site.
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Review |
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Interpreting breast international group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer
Meredith M Regan, Karen N Price, Anita Giobbie-Hurder, Beat Thürlimann, Richard D Gelber, for the International Breast Cancer Study Group and BIG 1-98 Collaborative Group Breast Cancer Research 2011, 13:209 (26 May 2011)
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Notch signaling as a therapeutic target for breast cancer treatment?
Jianxun Han, Michael J Hendzel, Joan Allalunis-Turner Breast Cancer Research 2011, 13:210 (31 May 2011)
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Breast cancer growth and metastasis: interplay between cancer stem cells, embryonic signaling pathways and epithelial-to-mesenchymal transition
Naoko Takebe, Ronald Q Warren, S Percy Ivy Breast Cancer Research 2011, 13:211 (10 June 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction
Pierre-Emmanuel Colombo, Fernanda Milanezi, Britta Weigelt, Jorge S Reis-Filho Breast Cancer Research 2011, 13:212 (27 June 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
In this review, the authors examine the clinical relevance of microarray-based profiling of breast cancer and discuss its impact on patient management.
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Report |
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Correction: Functional magnetic resonance: biomarkers of response in breast cancer
Elizabeth AM O'Flynn, Nandita M deSouza Breast Cancer Research 2011, 13:405 (30 June 2011)
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Research |
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Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II
A Heather Eliassen, Donna Spiegelman, Bruce W Hollis, Ronald L Horst, Walter C Willett, Susan E Hankinson Breast Cancer Research 2011, 13:R50 (11 May 2011)
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Coffee consumption modifies risk of estrogen-receptor negative breast cancer
Jingmei Li, Petra Seibold, Jenny Chang-Claude, Dieter Flesch-Janys, Jianjun Liu, Kamila Czene, Keith Humphreys, Per Hall Breast Cancer Research 2011, 13:R49 (14 May 2011)
Abstract | Full text | PDF | PubMed | F1000 Biology
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Editor’s summary
A Swedish study finds that a high daily intake of coffee is associated with a statistically significant decrease in estrogen receptor-negative breast cancer among postmenopausal women.
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Optimal tumor sampling for immunostaining of biomarkers in breast carcinoma
Juliana Tolles, Yalai Bai, Maria Baquero, Lyndsay N Harris, David L Rimm, Annette M Molinaro Breast Cancer Research 2011, 13:R51 (18 May 2011)
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Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
Yinghui Zhang, Marja Moerkens, Sreenivasa Ramaiahgari, Hans de Bont, Leo Price, John Meerman, Bob van de Water Breast Cancer Research 2011, 13:R52 (19 May 2011)
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Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells
Lauren Gardner, Rohit Malik, Yoshiko Shimizu, Nicole Mullins, Wael M ElShamy Breast Cancer Research 2011, 13:R53 (19 May 2011)
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Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silico based mechanism
Gloria Fuentes, Maurizio Scaltriti, José Baselga, Chandra S Verma Breast Cancer Research 2011, 13:R54 (22 May 2011)
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Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort study
Kristine H Allin, Børge G Nordestgaard, Henrik Flyger, Stig E Bojesen Breast Cancer Research 2011, 13:R55 (3 June 2011)
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Editor’s summary
Elevated pre-treatment levels of plasma C-reactive protein (CRP) are predictive of poorer prognosis and increased death rates in breast cancer patients regardless of menopause, lifestyle factors and cardiovascular disease.
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Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome
Lingeng Lu, Chong Zhang, Gongjian Zhu, Melinda Irwin, Harvey Risch, Guido Menato, Marco Mitidieri, Dionyssios Katsaros, Herbert Yu Breast Cancer Research 2011, 13:R56 (6 June 2011)
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Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes
Michael L Gatza, Hsiu-Ni Kung, Kimberly L Blackwell, Mark W Dewhirst, Jeffrey R Marks, Jen-Tsan Chi Breast Cancer Research 2011, 13:R62 (7 June 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Impact of UGT2B7 His268Tyr
polymorphism on the outcome of adjuvant epirubicin treatment in breast cancer
Sumit Parmar, Julia Stingl, Ariana Huber-Wechselberger, Alexander Kainz, Wilfried Renner, Uwe Langsenlehner, Peter Krippl, Jürgen Brockmöller, Elisabeth Haschke-Becher Breast Cancer Research 2011, 13:R57 (9 June 2011)
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Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells
Craig A Cooney, Fariba Jousheghany, Aiwei Yao-Borengasser, Bounleut Phanavanh, Tina Gomes, Ann Kieber-Emmons, Eric R Siegel, Larry J Suva, Soldano Ferrone, Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi Breast Cancer Research 2011, 13:R58 (9 June 2011)
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Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients
Galatea Kallergi, Maria A Papadaki, Eleni Politaki, Dimitris Mavroudis, Vassilis Georgoulias, Sophia Agelaki Breast Cancer Research 2011, 13:R59 (10 June 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients with operable breast cancer: prognostic relevance for late relapse
Emmanouil Saloustros, Maria Perraki, Stella Apostolaki, Galatea Kallergi, Alexandros Xyrafas, Kostas Kalbakis, Sophia Agelaki, Antonia Kalykaki, Vassilis Georgoulias, Dimitris Mavroudis Breast Cancer Research 2011, 13:R60 (10 June 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The prognostic significance of tumour cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients
Timothy J Molloy, Astrid J Bosma, Lars O Baumbusch, Marit Synnestvedt, Elin Borgen, Hege Russnes, Ellen Schlichting, Laura J van't Veer, Bjørn Naume Breast Cancer Research 2011, 13:R61 (14 June 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications
Anthony G Clementz, Allison Rogowski, Kinnari Pandya, Lucio Miele, Clodia Osipo Breast Cancer Research 2011, 13:R63 (14 June 2011)
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Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment
Mario Giuliano, Antonio Giordano, Summer Jackson, Kenneth R Hess, Ugo De Giorgi, Michal Mego, Beverly C Handy, Naoto T Ueno, Ricardo H Alvarez, Michelino De Laurentiis, Sabino De Placido, Vicente Valero, Gabriel N Hortobagyi, James M Reuben, Massimo Cristofanilli Breast Cancer Research 2011, 13:R67 (15 June 2011)
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Cardiovascular disease competes with breast cancer as the leading cause of death for older females diagnosed with breast cancer: a retrospective cohort study
Jennifer L Patnaik, Tim Byers, Carolyn DiGuiseppi, Dana Dabelea, Thomas D Denberg Breast Cancer Research 2011, 13:R64 (20 June 2011)
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Editor’s summary
Two thirds of women with breast cancer die as a result of comorbid conditions, with cardiovascular disease the leading cause of death among older women diagnosed with breast cancer.
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Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells
Terry J Shackleford, Qingxiu Zhang, Ling Tian, Thuy T Vu, Anita L Korapati, Angela M Baumgartner, Xiao-Feng Le, Warren S Liao, Francois X Claret Breast Cancer Research 2011, 13:R65 (20 June 2011)
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Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3
Yasuo Kodera, Yasufumi Katanasaka, Yuka Kitamura, Hitoshi Tsuda, Kazuto Nishio, Tomohide Tamura, Fumiaki Koizumi Breast Cancer Research 2011, 13:R66 (21 June 2011)
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Impact of established prognostic factors and molecular subtype in very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials
Jos A van der Hage, J Sven D Mieog, Cornelis JH van de Velde, Hein Putter, Harry Bartelink, Marc J van de Vijver Breast Cancer Research 2011, 13:R68 (24 June 2011)
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Editor’s summary
Molecular subtype is a strong predictor of outcome in breast cancer patients under 40, suggesting future treatment guidelines should be based on tumour characteristics and not on age alone.
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Reversal of endocrine resistance in breast cancer: interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis
Anna Bergamaschi, Barbara L Christensen, Benita S Katzenellenbogen Breast Cancer Research 2011, 13:R70 (29 June 2011)
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Editor’s summary
14-3-3zeta is a key predictive marker for risk of failure on endocrine therapy and serves a pivotal role impacting growth factor signaling, and promoting cell survival and resistance to endocrine therapies.
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Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells
Binoj C Nair, Sreeram Vallabhaneni, Rajeshwar R Tekmal, Ratna K Vadlamudi Breast Cancer Research 2011, 13:R80 (11 August 2011)
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