miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
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Correspondence: Derek C Radisky radisky.derek@mayo.edu
Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
Breast Cancer Research 2011, 13:110 doi:10.1186/bcr2885
Published: 10 June 2011Abstract
Decreased expression of miRNAs of the miR-200 family has been implicated in the growth and metastasis of breast cancer cells. Of this family, miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2, mediators of epithelial- mesenchymal transition. An article in the previous issue of Breast Cancer Research identifies additional targets of miR-200c that link increased cancer cell invasiveness, resistance to apoptosis, and induction of breast cancer stem cell characteristics.