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Estrogen receptor degradation: a CUE for endocrine resistance?

Elizabeth A Musgrove

Author Affiliations

Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia

St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, NSW 2052, Australia

Breast Cancer Research 2011, 13:312  doi:10.1186/bcr2914

Published: 16 August 2011

Abstract

Despite the undoubted success of adjuvant endocrine therapies that target the estrogen receptor pathway, not all women with estrogen receptor-positive breast cancer respond to these therapies, and many who initially respond will subsequently relapse. Deregulation of various aspects of estrogen receptor signaling has been highlighted as a mechanism of resistance and as a basis for alternative therapeutic approaches. However, a recent publication refocuses attention on the estrogen receptor itself by showing that the ubiquitin-binding CUE domain-containing protein 2 is a regulator of estrogen receptor protein degradation and a marker of endocrine resistance in breast cancer.