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Volume 13 Issue 5
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Comment |
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Rats: gnawing through the barriers to understanding genetic susceptibility and breast cancer
Anneke C Blackburn Breast Cancer Research 2011, 13:112 (12 October 2011)
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A protective role for BRCA2 at stalled replication forks
Gurushankar Chandramouly, Nicholas A Willis, Ralph Scully Breast Cancer Research 2011, 13:314 (7 September 2011)
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The amplifier effect: how Pin1 empowers mutant p53
Hai Hu, Gerburg M Wulf Breast Cancer Research 2011, 13:315 (13 October 2011)
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Review |
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Male breast carcinoma: increased awareness needed
Jonathan White, Olive Kearins, David Dodwell, Kieran Horgan, Andrew M Hanby, Valerie Speirs Breast Cancer Research 2011, 13:219 (29 September 2011)
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Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer
Priscilla A Furth, Rebecca E Nakles, Sarah Millman, Edgar S Diaz-Cruz, M Carla Cabrera Breast Cancer Research 2011, 13:220 (12 October 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Three interrelated themes in current breast cancer research: gene addiction, phenotypic plasticity, and cancer stem cells
Robert D Cardiff, Suzana Couto, Brad Bolon Breast Cancer Research 2011, 13:216 (25 October 2011)
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Minimal residual disease and circulating tumor cells in breast cancer
Michail Ignatiadis, Monica Reinholz Breast Cancer Research 2011, 13:222 (25 October 2011)
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Report |
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The devil is in the methods: lineage tracing, functional screens and sequencing, hormones, tumour-stroma interactions, and expansion of human breast tumours as xenografts
María dM Vivanco, John Stingl, Robert B Clarke, Mohamed Bentires-Alj Breast Cancer Research 2011, 13:316 (14 October 2011)
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Research |
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Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients
Hitesh N Appaiah, Chirayu P Goswami, Lida A Mina, Sunil Badve, George W Sledge, Yunlong Liu, Harikrishna Nakshatri Breast Cancer Research 2011, 13:R86 (13 September 2011)
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Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study
Harri Sihto, Johan Lundin, Mikael Lundin, Tiina Lehtimäki, Ari Ristimäki, Kaija Holli, Liisa Sailas, Vesa Kataja, Taina Turpeenniemi-Hujanen, Jorma Isola, Päivi Heikkilä, Heikki Joensuu Breast Cancer Research 2011, 13:R87 (13 September 2011)
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Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL
Luke Piggott, Nader Omidvar, Salvador Pérez, Matthias Eberl, Richard WE Clarkson Breast Cancer Research 2011, 13:R88 (14 September 2011)
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Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK
Kristopher A Lofgren, Julie H Ostrander, Daniel Housa, Gregory K Hubbard, Alessia Locatelli, Robin L Bliss, Kathryn L Schwertfeger, Carol A Lange Breast Cancer Research 2011, 13:R89 (17 September 2011)
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Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications
Taru A Muranen, Dario Greco, Rainer Fagerholm, Outi Kilpivaara, Kati Kämpjärvi, Kristiina Aittomäki, Carl Blomqvist, Päivi Heikkilä, Åke Borg, Heli Nevanlinna Breast Cancer Research 2011, 13:R90 (20 September 2011)
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The chemokine receptor CX3CR1 is directly involved in the arrest of breast cancer cells to the skeleton
Whitney L Jamieson-Gladney, Yun Zhang, Alan M Fong, Olimpia Meucci, Alessandro Fatatis Breast Cancer Research 2011, 13:R91 (20 September 2011)
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A new gene expression signature, the ClinicoMolecular Triad Classification, may improve prediction and prognostication of breast cancer at the time of diagnosis
Dong-Yu Wang, Susan J Done, David R McCready, Scott Boerner, Supriya Kulkarni, Wey Leong Breast Cancer Research 2011, 13:R92 (22 September 2011)
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erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines
Janice M Knowlden, Julia MW Gee, Denise Barrow, John F Robertson, Ian O Ellis, Robert I Nicholson, Iain R Hutcheson Breast Cancer Research 2011, 13:R93 (22 September 2011)
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Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor
Adriana S Beltran, Ashley G Rivenbark, Bryan T Richardson, Xinni Yuan, Haili Quian, John P Hunt, Eric Zimmerman, Lee M Graves, Pilar Blancafort Breast Cancer Research 2011, 13:R94 (27 September 2011)
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Genomic and phenotypic analysis of BRCA2 mutated breast cancers reveals co-occurring changes linked to progression
Olafur A Stefansson, Jon G Jonasson, Kristrun Olafsdottir, Hordur Bjarnason, Oskar Th Johannsson, Sigridur K Bodvarsdottir, Sigridur Valgeirsdottir, Jorunn E Eyfjord Breast Cancer Research 2011, 13:R95 (29 September 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Transglutaminase 2 facilitates the distant hematogenous metastasis of breast cancer by modulating interleukin-6 in cancer cells
Keunhee Oh, Eunyoung Ko, Hee Kim, Ae Park, Hyeong-Gon Moon, Dong-Young Noh, Dong-Sup Lee Breast Cancer Research 2011, 13:R96 (3 October 2011)
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A clinically relevant gene signature in triple negative and basal-like breast cancer
Achim Rody, Thomas Karn, Cornelia Liedtke, Lajos Pusztai, Eugen Ruckhaeberle, Lars Hanker, Regine Gaetje, Christine Solbach, Andre Ahr, Dirk Metzler, Marcus Schmidt, Volkmar Müller, Uwe Holtrich, Manfred Kaufmann Breast Cancer Research 2011, 13:R97 (6 October 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer
Rachel C Jankowitz, Kristine Cooper, Mark G Erlander, Xiao-Jun Ma, Nicole C Kesty, Hongying Li, Mamatha Chivukula, Adam Brufsky Breast Cancer Research 2011, 13:R98 (14 October 2011)
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Editor’s summary
Breast Cancer Index is a significant predictor of distant recurrence and breast-cancer specific mortality; Adjuvant! Online was significantly associated with risk of recurrence; and both are significantly predictive of outcome.
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The combined influence of multiple sex and growth hormones on risk of postmenopausal breast cancer: a nested case-control study
Shelley S Tworoger, Bernard A Rosner, Walter C Willett, Susan E Hankinson Breast Cancer Research 2011, 13:R99 (21 October 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
The presence of several sex and growth hormones at high levels increases breast cancer risk particularly for ER+ disease, and this observation should be considered when improving existing risk prediction models.
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Nondense mammographic area and risk of breast cancer
Andreas Pettersson, Susan E Hankinson, Walter C Willett, Pagona Lagiou, Dimitrios Trichopoulos, Rulla M Tamimi Breast Cancer Research 2011, 13:R100 (21 October 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Higher absolute non-dense area on a mammogram is associated with a decreased risk of breast cancer, suggesting adipose breast tissue may have a protective role against breast carcinogenesis.
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Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB
Li Wei, Tsung-Ta Liu, Hsiu-Huan Wang, Hui-Mei Hong, Alice L Yu, Hsiang-Pu Feng, Wen-Wei Chang Breast Cancer Research 2011, 13:R101 (24 October 2011)
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Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts
Ashley L Hilchie, Carolyn D Doucette, Devanand M Pinto, Aleksander Patrzykat, Susan Douglas, David W Hoskin Breast Cancer Research 2011, 13:R102 (24 October 2011)
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Editor’s summary
Pleurocidin-family cationic antimicrobial peptides are cytotoxic for multiple breast cancer cell lines and prevent growth of tumour xenografts, suggesting the possible use of NRC-03 and NRC-07 as novel anticancer agents.
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Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue
Mariëtte Lokate, Petra HM Peeters, Linda M Peelen, Gerco Haars, Wouter B Veldhuis, Carla H van Gils Breast Cancer Research 2011, 13:R103 (26 October 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
When studying the relationship between breast dense area and breast cancer risk, adjustments for non-dense tissue may give more valid results than adjustment for BMI.
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Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation
Ahmed M Kotb, Andreas Hierholzer, Rolf Kemler Breast Cancer Research 2011, 13:R104 (26 October 2011)
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MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases
Eliana Pivetta, Martina Scapolan, Marina Pecolo, Bruna Wassermann, Imad Abu-Rumeileh, Luca Balestreri, Eugenio Borsatti, Claudio Tripodo, Alfonso Colombatti, Paola Spessotto Breast Cancer Research 2011, 13:R105 (27 October 2011)
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Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFβ-dependent expression of the Wnt antagonist, sclerostin
Daniel Mendoza-Villanueva, Leo Zeef, Paul Shore Breast Cancer Research 2011, 13:R106 (27 October 2011)
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Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness
Esther H Lips, Nadja Laddach, Suvi P Savola, Marieke A Vollebergh, Anne MM Oonk, Alex LT Imholz, Lodewyk FA Wessels, Jelle Wesseling, Petra M Nederlof, Sjoerd Rodenhuis Breast Cancer Research 2011, 13:R107 (27 October 2011)
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Evaluation of prognostic and predictive value of microtubule associated protein tau in two independent cohorts
Maria T Baquero, Karen Lostritto, Mark D Gustavson, Kimberly A Bassi, Franck Appia, Robert L Camp, Annette M Molinaro, Lyndsay N Harris, David L Rimm Breast Cancer Research 2011, 13:R85 (2 November 2011)
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Detection of breast cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors
Helen J Hathaway, Kimberly S Butler, Natalie L Adolphi, Debbie M Lovato, Robert Belfon, Danielle Fegan, Todd C Monson, Jason E Trujillo, Trace E Tessier, Howard C Bryant, Dale L Huber, Richard S Larson, Edward R Flynn Breast Cancer Research 2011, 13:R108 (3 November 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Antibody-conjugated magnetic nanoparticles and superconducting quantum interference device sensors may provide a useful, viable and highly-sensitive alternative to mammographic screening in breast tumor cell detection.
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