Additional file 11.
Figure S5. Tumor suppressor genes in OTBCs are re-expressed upon treatment with DNA methyltransferase and histone deacetylase inhibitors. OTBCs86-L1 and OTBCs48-1 lines were treated with 5 M of 5-aza-2'-deoxycytodine (5-Aza-2'dC), 0.5 M Suberoylanilide Hydroxamic Acid (SAHA), and 100 nM Trichostatin-A (TSA) for 48 hours and gene expression was assessed by RT-PCR. Bar graphs represent the mean SD of three independent experiments. Data was analyzed with student t test and p-values were set at p 0.05. (a) Expression levels of Maspin and CDH1 were normalized to vehicle control (b) Expression levels of MGMT and DKK1 normalized to vehicle control.
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Beltran et al. Breast Cancer Research 2011 13:R94 doi:10.1186/bcr3019