Steps solidifying a role for SEPT9 in breast cancer suggest that greater strides are needed
1 University of Michigan Medical School, Department of Internal Medicine-Hematology/Oncology, 7111 Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
2 University of Wisconsin School of Medicine and Public Health, 4121 Health Sciences Learning Center, 750 Highland Ave, Madison, WI 53705, USA
Breast Cancer Research 2012, 14:101 doi:10.1186/bcr3056
See related research by Connolly et al., http://breast-cancer-research.com/content/13/4/R76Published: 9 January 2012
Septins comprise a conserved family of GTPase proteins. Of these, human SEPT9 has been widely implicated in cancers of epithelial origin, including breast cancer, as well as leukemia. In a previous issue of Breast Cancer Research, Connolly and colleagues present compelling data further supporting a role for SEPT9 isoforms in early breast cancer development as well as evidence suggesting that cellular localization patterns of SEPT9 isoforms may contribute to oncogenesis.