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New insights into signalling networks regulating breast cancer stem cells

Alexander Swarbrick12 and Roger J Daly12*

Author Affiliations

1 Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, NSW 2010, Australia

2 St Vincent's Hospital Clinical School, University of New South Wales, Sydney, NSW 2052, Australia

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Breast Cancer Research 2012, 14:321  doi:10.1186/bcr3209

Published: 21 September 2012

Abstract

In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target.