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Highly Accessed Review

Patient-derived breast tumor xenografts facilitating personalized cancer therapy

Melissa D Landis1*, Brian D Lehmann2, Jennifer A Pietenpol2 and Jenny C Chang13*

Author Affiliations

1 The Methodist Cancer Center, Houston, TX 77030, USA

2 Department of Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Preston Research Building, 2200 Pierce Avenue, Nashville, TN 37232, USA

3 Weill Cornell Medical School, NY, NY 10065, USA

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Breast Cancer Research 2013, 15:201  doi:10.1186/bcr3355

Published: 22 January 2013

Abstract

Despite improved detection and reduction of breast cancer-related deaths over the recent decade, breast cancer remains the second leading cause of cancer death for women in the US, with 39,510 women expected to succumb to metastatic disease in 2012 alone (American Cancer Society, Cancer Facts &Figures 2012. Atlanta: American Cancer Society; 2012). Continued efforts in classification of breast cancers based on gene expression profiling and genomic sequencing have revealed an underlying complexity and molecular heterogeneity within the disease that continues to challenge therapeutic interventions. To successfully identify and translate new treatment regimens to the clinic, it is imperative that our preclinical models recapitulate this complexity and heterogeneity. In this review article, we discuss the recent advances in development and classification of patient-derived human breast tumor xenograft models that have the potential to facilitate the next phase of drug discovery for personalized cancer therapy based on the unique driver signaling pathways in breast tumor subtypes.