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Elf5 - breast cancer's little helper

Hayley T Frend and Christine J Watson*

Author Affiliations

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK

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Breast Cancer Research 2013, 15:307  doi:10.1186/bcr3397

Published: 27 March 2013

Abstract

A variety of transcription factors has been shown to regulate lineage commitment in the mammary gland and to be associated with different molecular subtypes of breast cancer. E74-like factor 5 (Elf5) has now been identified as a marker of oestrogen receptor status, and high expression correlates with more aggressive basal cancers and resistance to anti-oestrogens. Manipulation of Elf5 transcript levels perturbs the molecular profiles of luminal and basal subtypes, highlighting the possibility that targeting Elf5 could provide a new approach for the treatment of basal cancers.