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Enzyme-prodrug systems under investigation for genetic prodrug activation therapy applications |
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| Enzyme |
Prodrug |
Cytotoxic product |
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|
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| Herpes simplex virus thymidine kinase |
Ganciclovir |
Ganciclovir triphosphate |
| Cytosine deaminase |
5-Fluorocytosine |
5-Fluorouracil |
| Varicella zoster virus thymidine kinase |
6-Methoxypurine arabinose |
Adenine arabinonucleoside triphosphate |
| Nitroreductase |
CB1954 |
5-Aziridinyl-4-hydroxylamino-2-nitrobenzamide |
| Cytochrome p450 |
Cyclophosphamide |
Acrolein and phosphoramide mustard |
| Thymidine phosphorylase |
5' -Deoxy-5-fluorouridine |
5-Fluorouracil |
| Purine nucleoside phosphorylase |
6-Methylpurine-deoxyriboside |
6-Methylpurine |
| Alkaline phosphatase |
Etoposide phosphate |
Etoposide |
| Carboxypeptidase A |
Methotrexate-alanine |
Methotrexate |
| Carboxypeptidase G2 |
Benzoic acid mustard-glucuronide |
Benzoic acid mustard |
| Linamarase |
Linamarin |
Cyanide |
| Xanthine oxidase |
Xanthine |
Oxygen radicals |
| β -Lactamase |
Cephalosporin-mustard-carbamate |
Nitrogen mustard |
Vassaux and Lemoine Breast Cancer Res 2000 2:22 doi:10.1186/bcr25 |
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