Figure 1.

The phosphoinositide 3-kinase (PI3K) superfamily. Schematic representation of the catalytic subunits of the PI3K superfamily of enzymes. The names of the kinases are given on the left, together with their size (kDa). Classification by class is indicated by the bars on the right. Recognised domains are indicated. ATM/ATR/DNA-PK, Ataxia telangiectasia mutated/ataxia telangiectasia related/DNA-dependent protein kinase; FAT, domain present in FKBP rapamycin-associated protein/target of rapamycin (TOR), ATM and TRRAP (ATM-related) proteins; FATC, C-terminal domain found only in FAT domain containing proteins; FRB, FKBP12/rapamycin binding domain; HEAT, domain found in Huntington, EF3, a subunit of protein phosphatase 2A and TOR; HR1-HR4, homology region; p85 BD, p85 binding domain; PH, pleckstrin homology; PX, phox homology; RBD, Ras binding domain.