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Highly Accessed Review

Breast cancer cell lines: friend or foe?

Sarah E Burdall12, Andrew M Hanby3, Mark RJ Lansdown2 and Valerie Speirs1*

Author Affiliations

1 Molecular Medicine Unit, University of Leeds, Leeds, UK

2 Breast Unit, St James's University Hospital, Leeds, UK

3 Academic Unit of Pathology, University of Leeds, Leeds, UK

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Breast Cancer Res 2003, 5:89-95  doi:10.1186/bcr577

Published: 3 February 2003

Abstract

The majority of breast cancer research is conducted using established breast cancer cell lines as in vitro models. An alternative is to use cultures established from primary breast tumours. Here, we discuss the pros and cons of using both of these models in translational breast cancer research.

Keywords:
cell culture; in vitro models; mammary gland