Table 3 |
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Relationships between breast cancer and putative risk factors by CYP17 genotype: Western New York Breast Cancer Study |
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|
All data |
A1/A1 |
A1/A2 and A2/A2 |
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|
|
|
|
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|
Case (n [%]) |
Control (n [%]) |
Odds ratio (95% CI)a |
Case (n [%]) |
Control (n [%]) |
Odds ratio (95% CI)a |
Case (n [%]) |
Control (n [%]) |
Odds ratio (95% CI)a |
|
|
|
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|
Premenopausal |
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|
Age at menarche |
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|
< 13 years |
47 (50) |
33 (39) |
1.00 |
30 (52) |
15 (31) |
1.00 |
17 (46) |
18 (49) |
1.00 |
|
≥ 13 years |
48 (51) |
52 (61) |
0.55 (0.27–1.10) |
28 (48) |
33 (69) |
0.37 (0.14–0.99) |
20 (54) |
19 (51) |
0.84 (0.27–2.61) |
|
Age at first birth |
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|
< 25 years |
55 (57) |
66 (77) |
1.00 |
34 (59) |
38 (79) |
1.00 |
21 (55) |
28 (74) |
1.00 |
|
≥ 25 years |
41 (43) |
20 (23) |
2.69 (1.34–5.39) |
24 (41) |
10 (21) |
4.30 (1.46–12.67) |
17 (45) |
10 (26) |
2.13 (0.76–6.02) |
|
Difficulty getting pregnant |
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|
No |
82 (79) |
79 (81) |
1.00 |
40 (71) |
38 (79) |
1.00 |
33 (89) |
29 (76) |
1.00 |
|
Yes |
22 (21) |
19 (19) |
0.97 (0.44–2.14) |
16 (29) |
10 (21) |
2.23 (0.69–7.24) |
4 (11) |
9 (24) |
0.38 (0.10–1.52) |
|
Ever use oral contraceptives |
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|
No |
44 (46) |
45 (52) |
1.00 |
24 (41) |
26 (54) |
1.00 |
20 (53) |
19 (50) |
1.00 |
|
Yes |
52 (54) |
41 (48) |
1.77 (0.84–3.74) |
34 (59) |
22 (46) |
3.24 (1.08–9.73) |
18 (47) |
19 (50) |
0.67 (0.20–2.26) |
|
Postmenopausal |
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|
Age at menarche |
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|
< 13 years |
56 (50) |
43 (42) |
1.00 |
25 (48) |
18 (38) |
1.00 |
31 (52) |
25 (46) 1.00 |
|
|
≥ 13 years |
56 (50) |
59 (58) |
0.78 (0.42–1.48) |
27 (52) |
29 (62) |
0.72 (0.27–1.91) |
29 (48) |
30 (55) |
0.80 (0.33–1.93) |
|
Age at first birth |
|||||||||
|
< 25 years |
60 (54) |
61 (60) |
1.00 |
29 (57) |
21 (48) |
1.00 |
31 (52) |
40 (73) |
1.00 |
|
≥ 25 years |
51 (46) |
41 (40) |
1.52 (0.83–2.77) |
22 (43) |
26 (55) |
0.68 (0.27–1.68) |
29 (48) |
15 (27) |
2.90 (1.30–6.97) |
|
Difficulty getting pregnant |
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|
No |
82 (79) |
79 (81) |
1.00 |
42 (86) |
32 (74) |
1.00 |
40 (73) |
47 (85) |
1.00 |
|
Yes |
22 (21) |
19 (19) |
1.19 (0.58–2.41) |
7 (14) |
11 (26) |
0.47 (0.14–1.50) |
15 (27) |
8 (15) |
2.59 (0.91–7.38) |
|
Ever use hormone replacement therapy |
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|
No |
89 (80) |
71 (70) |
1.00 |
40 (77) |
32 (68) |
1.00 |
49 (82) |
39 (71) |
1.00 |
|
Yes |
23 (20) |
31 (30) |
0.94 (0.31–2.78) |
12 (23) |
15 (32) |
0.80 (0.14–4.52) |
11 (18) |
16 (29) |
0.98 (0.23–4.26) |
|
Age at menopause |
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|
< 48 years |
58 (47) |
58 (57) |
1.00 |
24 (47) |
29 (62) |
1.00 |
29 (48) |
29 (53) |
1.00 |
|
≥ 48 years |
58 (52) |
44 (43) |
1.60 (0.91–2.84) |
27 (53) |
18 (38) |
1.98 (0.84–4.68) |
31 (52) |
26 (47) |
1.36 (0.61–3.06) |
|
|
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|
a Adjusted for other factors in the table as well as age, education, family history of breast cancer, history of benign breast disease, and body mass index. CI, confidence interval. |
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|
Ambrosone et al. Breast Cancer Res 2003 5:R45 doi:10.1186/bcr570 |
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