Table 3

Relationships between breast cancer and putative risk factors by CYP17 genotype: Western New York Breast Cancer Study

All data

A1/A1

A1/A2 and A2/A2




Case (n [%])

Control (n [%])

Odds ratio (95% CI)a

Case (n [%])

Control (n [%])

Odds ratio (95% CI)a

Case (n [%])

Control (n [%])

Odds ratio (95% CI)a


Premenopausal

Age at menarche

< 13 years

47 (50)

33 (39)

1.00

30 (52)

15 (31)

1.00

17 (46)

18 (49)

1.00

≥ 13 years

48 (51)

52 (61)

0.55 (0.27–1.10)

28 (48)

33 (69)

0.37 (0.14–0.99)

20 (54)

19 (51)

0.84 (0.27–2.61)

Age at first birth

< 25 years

55 (57)

66 (77)

1.00

34 (59)

38 (79)

1.00

21 (55)

28 (74)

1.00

≥ 25 years

41 (43)

20 (23)

2.69 (1.34–5.39)

24 (41)

10 (21)

4.30 (1.46–12.67)

17 (45)

10 (26)

2.13 (0.76–6.02)

Difficulty getting pregnant

No

82 (79)

79 (81)

1.00

40 (71)

38 (79)

1.00

33 (89)

29 (76)

1.00

Yes

22 (21)

19 (19)

0.97 (0.44–2.14)

16 (29)

10 (21)

2.23 (0.69–7.24)

4 (11)

9 (24)

0.38 (0.10–1.52)

Ever use oral contraceptives

No

44 (46)

45 (52)

1.00

24 (41)

26 (54)

1.00

20 (53)

19 (50)

1.00

Yes

52 (54)

41 (48)

1.77 (0.84–3.74)

34 (59)

22 (46)

3.24 (1.08–9.73)

18 (47)

19 (50)

0.67 (0.20–2.26)

Postmenopausal

Age at menarche

< 13 years

56 (50)

43 (42)

1.00

25 (48)

18 (38)

1.00

31 (52)

25 (46) 1.00

≥ 13 years

56 (50)

59 (58)

0.78 (0.42–1.48)

27 (52)

29 (62)

0.72 (0.27–1.91)

29 (48)

30 (55)

0.80 (0.33–1.93)

Age at first birth

< 25 years

60 (54)

61 (60)

1.00

29 (57)

21 (48)

1.00

31 (52)

40 (73)

1.00

≥ 25 years

51 (46)

41 (40)

1.52 (0.83–2.77)

22 (43)

26 (55)

0.68 (0.27–1.68)

29 (48)

15 (27)

2.90 (1.30–6.97)

Difficulty getting pregnant

No

82 (79)

79 (81)

1.00

42 (86)

32 (74)

1.00

40 (73)

47 (85)

1.00

Yes

22 (21)

19 (19)

1.19 (0.58–2.41)

7 (14)

11 (26)

0.47 (0.14–1.50)

15 (27)

8 (15)

2.59 (0.91–7.38)

Ever use hormone replacement therapy

No

89 (80)

71 (70)

1.00

40 (77)

32 (68)

1.00

49 (82)

39 (71)

1.00

Yes

23 (20)

31 (30)

0.94 (0.31–2.78)

12 (23)

15 (32)

0.80 (0.14–4.52)

11 (18)

16 (29)

0.98 (0.23–4.26)

Age at menopause

< 48 years

58 (47)

58 (57)

1.00

24 (47)

29 (62)

1.00

29 (48)

29 (53)

1.00

≥ 48 years

58 (52)

44 (43)

1.60 (0.91–2.84)

27 (53)

18 (38)

1.98 (0.84–4.68)

31 (52)

26 (47)

1.36 (0.61–3.06)


a Adjusted for other factors in the table as well as age, education, family history of breast cancer, history of benign breast disease, and body mass index. CI, confidence interval.

Ambrosone et al. Breast Cancer Res 2003 5:R45-R51   doi:10.1186/bcr570

Open Data