Host microenvironment in breast cancer development: Extracellular matrix–stromal cell contribution to neoplastic phenotype of epithelial cells in the breast
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* Corresponding author: Malathy PV Shekhar shekharm@karmanos.org
Breast Cancer Res 2003, 5:130-135 doi:10.1186/bcr580
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Athina-Myrto Chioni, Richard Grose Fibrogenesis & Tissue Repair 2008, 1:8 (11 December 2008) |
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Collagen density promotes mammary tumor initiation and progression Paolo P Provenzano, David R Inman, Kevin W Eliceiri, Justin G Knittel, Long Yan, Curtis T Rueden, John G White, Patricia J Keely BMC Medicine 2008, 6:11 (28 April 2008) Increased stromal collagen density in mouse mammary tissue increases both tumor formation and tumor cell invasive and migratory properties by three fold; furthermore, a metabolic signature for flavin adenine dinucleotide is identified in invading metastatic cells.
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