Inflammatory breast cancer: Vasculogenic mimicry and its hemodynamics of
an inflammatory breast cancer xenograft model

doi:10.1186/bcr585

Breast Cancer Res

Volume 5
Issue 3

Viewing options:

Abstract
Full text
PDF (912KB)

Associated material:

Related literature:

Articles citing this article
on BioMed Central
on Google Scholar
on ISI Web of Science
on PubMed Central
Other articles by authors
on Google Scholar

Shirakawa K
Kobayashi H
Sobajima J
Hashimoto D
Shimizu A
Wakasugi H

on PubMed

Shirakawa K
Kobayashi H
Sobajima J
Hashimoto D
Shimizu A
Wakasugi H
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

This article is part of a series on Inflammatory breast cancer, edited by Sofia Merajver.

Review

Inflammatory breast cancer: Vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model

Kazuo Shirakawa¹^,2 , Hisataka Kobayashi³, Jun Sobajima¹, Daijo Hashimoto¹, Atsushi Shimizu² and Hiro Wakasugi²

¹Department of Surgery, Kawagoe Medical Center, Saitama Medical School, Saitama, Japan

²Pharmacology Division, National Cancer Center Research Institute, Tokyo, Japan

³Hitachi Medical Co, Department of Diagnostic and Interventional Imagiology, Kyoto, Japan

author email corresponding author email

Breast Cancer Res 2003, 5:136-139doi:10.1186/bcr585


Published:	6 March 2003

This article is the first in a review series on Inflammatory breast cancer, edited by Sofia Merajver. Other articles in the series can be found at http://breast-cancer-research.com/articles/series.asp?rqs=merajver

Abstract

We recently established a new human inflammatory breast cancer (IBC) xenograft (WIBC-9) originating from a patient with IBC. The original tumor and WIBC-9 revealed invasive ductal carcinoma with a hypervascular structure of solid nests and marked lymphatic permeation in the overlying dermis. In the central part of the solid nests, vasculogenic mimicry, which showed an absence of endothelial cells, was observed. Comparison of WIBC-9 with an established non-IBC xenograft (MC-5), using time-course dynamic micro-magnetic resonance angiography analysis (with a newly developed intravascular macromolecular contrast agent for magnetic resonance imaging) demonstrated that the WIBC-9 tumor had blood flow and a vascular mimicry–angiogenesis junction.