Breast Cancer Res
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This article is part of a series on
Inflammatory breast cancer, edited by Sofia Merajver.ReviewInflammatory breast cancer: Relationship between growth factor signaling and motility in aggressive cancersKenneth L van Golen  Department of Internal Medicine, Division of Hematology/Oncology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA  author email corresponding author email
Breast Cancer Res 2003,
5:174-179doi:10.1186/bcr598 Abstract
A variety of phenotypic characteristics are required for a cancer cell to successfully complete the metastatic cascade. Acquisition of a motile and invasive phenotype is one requirement for a cell to become metastatically competent. The Rho (Ras homology) GTPases are a subfamily of small GTP-binding proteins, which are related to the Ras oncogene. All aspects of cellular motility and invasion are controlled by the Rho GTPases and are closely linked to signals from the extracellular environment, particularly in response to growth factors. Dysregulation of Rho activation through aberrant growth-factor signaling, loss of function of key Rho-regulatory proteins or overexpression of Rho mRNA could result in increased Rho activity and cellular motility. Therefore, the importance of the Rho GTPases in the progression of aggressive cancers, is becoming more appreciated. | 
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