Lack of evidence for an association of Epstein–Barr virus infection with breast carcinoma – authors' response

doi:10.1186/bcr604

Breast Cancer Res

Volume 5
Issue 4

Viewing options:

Abstract
Full text
PDF (30KB)

Associated material:

PubMed record

Related literature:

Articles citing this article
on Google Scholar
on ISI Web of Science
on PubMed Central
Other articles by authors
on Google Scholar

Niedobitek G
Murray PG
Young LS

on PubMed

Niedobitek G
Murray PG
Young LS
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

Letter

Lack of evidence for an association of Epstein–Barr virus infection with breast carcinoma – authors' response

Gerald Niedobitek¹ , Paul G Murray² and Lawrence S Young³

¹Professor of Pathology, Institut für Pathologie, Friedrich-Alexander-Universität, Erlangen, Germany

²Senior Lecturer in Pathology, Institute for Cancer Studies, University of Birmingham, UK

³Professor of Cancer Biology, Institute for Cancer Studies, University of Birmingham, UK

author email corresponding author email

Breast Cancer Res 2003, 5:E7doi:10.1186/bcr604


Published:	30 April 2003

First paragraph (this article has no abstract)

In her letter, recently published in Breast Cancer Research, María Victoria Preciado points out that some published evidence suggests a possible association of breast cancer with Epstein–Barr virus (EBV) [1]. EBV DNA has been detected by PCR in up to 50% of cases (for a review see [2]), and expression of the EBV-encoded nuclear antigen EBNA1 has been demonstrated in approximately 40% of cases by immunohistochemistry using the mAb designated 2B4 [3]. In combination, these findings seem to implicate EBV in the pathogenesis of breast carcinoma. Interestingly, however, most investigators agree that the EBV-encoded RNAs (EBERs), a hallmark of latent EBV infection, are not detectable in breast carcinoma tumour cells [2].