Figure 3.

The discriminatory power of CTX markers and CTX ratios to identify breast cancer-induced bone metastases. Open circles, individual Z scores for hypercalcemic patients with bone metastases (HC+) and normocalcemic patients with bone metastases (NC+). Z scores are calculated using the mean and standard deviation of normocalcemic breast cancer controls without bone metastases. αD = D-aspartyl peptide; αL = L-aspartyl peptide; βL = L-isoaspartyl peptide; CTX, crosslinked C-telopeptide of type I collagen.