Breast Cancer Research

official impact factor 5.79
Search for
Advanced search
Breast Cancer Research
Tools
Share this article
Review

The diagnosis and management of pre-invasive breast disease: Pathology of atypical lobular hyperplasia and lobular carcinoma in situ

Peter T Simpson1, Theodora Gale1, Laura G Fulford1,2, Jorge S Reis-Filho1 and Sunil R Lakhani1,3*

Author Affiliations

1 The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK

2 The Ludwig Institute for Cancer Research, London, UK

3 The Royal Marsden Hospital, London, UK

For all author emails, please log on.

Breast Cancer Res 2003, 5:258-262 doi:10.1186/bcr624

Published: 29 July 2003

Abstract

The term lobular neoplasia refers to a spectrum of lesions featuring atypical lobular hyperplasia and lobular carcinoma in situ (LCIS). The histopathological characteristics of these lesions are well documented. What is less well understood is the management implications of a patient diagnosed with LCIS; treatment regimes vary and are somewhat controversial. LCIS is now considered a risk factor and a non-obligate precursor for the subsequent development of invasive cancer.

Keywords:
atypical lobular hyperplasia; breast cancer; lobular carcinoma in situ; lobular neoplasia; precursor lesion