Figure 1.

Staining patterns of breast cancers with monoclonal antibody against CXCR4. Tumors consist of carcinoma cells with different immunoreactivities, defined as focal type (A, D). (A) Carcinoma cells located at the upper left area were positively stained, whereas cells in lower right area were negative. (D) Each cell shows a different immunoreactivity for CXCR4; the arrow and arrowhead indicate representative positive and negative carcinoma cells, respectively. In other cases, most carcinoma cells are diffusely and homogeneously stained, but the staining intensity differs between the high (B, E) and low (C, F) expression groups. Original magnifications: ×40 (A–C); ×200 (D–F). Scale bars, 20 μm.